BioAssay by Target (List) for Gene (Select 6046) - PubChem BioAssay - NCBI

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Select item 19582841.

Binding affinity to human partial length BRD2 bromodomain 2 isoform 1 (E348 to D455 residues) expressed in bacterial expression system by BROMOscan assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:2 Active, 4 Tested

AID:: 1958284

Summary Related BioAssays by Target

Select item 19582832.

Binding affinity to human partial length BRD2 bromodomain 1/2 isoform 1 (K71 to D455 residues) by BROMOscan assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:3 Active, 4 Tested

AID:: 1958283

Summary Related BioAssays by Target

Select item 19582823.

Binding affinity to human partial length BRD2 bromodomain 1 long isoform (K71 to N194 residues) expressed in bacterial expression system by BROMOscan assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:2 Active, 4 Tested

AID:: 1958282

Summary Related BioAssays by Target

Select item 19498004.

Inhibition of BRD2/3 (unknown origin)

Source:: ChEMBL

Protein Targets:: Bromodomain-containing protein 2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1949800

Summary Related BioAssays by Target

Select item 19491895.

Selectivity ratio of IC50 for displacement of biotinylated JQ1 from BRD2 BD1 (unknown origin) to IC50 for displacement of biotinylated JQ1 from BRD2 BD2 (unknown origin) by AlphaLisa assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Tested

AID:: 1949189

Summary Related BioAssays by Target

Select item 19427416.

Induction of BRD2 degradation (unknown origin) relative to control

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Tested

AID:: 1942741

Summary Related BioAssays by Target

Select item 19427387.

Induction of BRD2 degradation (unknown origin)

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1942738

Summary Related BioAssays by Target

Select item 19399038.

Binding affinity to BRD2 BD1 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939903

Summary Related BioAssays by Target

Select item 19398939.

Protac activity at BRD2/VHL-bound E3 ligase in human 22Rv1 cells assessed as reduction c-Myc level incubated for 24 hrs by Western blot analysis

Source:: ChEMBL

Protein Targets:: Bromodomain-containing protein 2; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939893

Summary Related BioAssays by Target

Select item 193988610.

Induction of BRD2 degradation in human LNCaP-95 cells incubated for 16 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939886

Summary Related BioAssays by Target

Select item 193988511.

Induction of BRD2 degradation in human VCaP cells incubated for 16 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939885

Summary Related BioAssays by Target

Select item 193988412.

Induction of BRD2 degradation in human 22Rv cells incubated for 16 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939884

Summary Related BioAssays by Target

Select item 193988113.

Binding affinity to BRD2 (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939881

Summary Related BioAssays by Target

Select item 193929714.

Binding affinity to BDR2- BD2 (unknown origin) by TR-FRET assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939297

Summary Related BioAssays by Target

Select item 193929615.

Binding affinity to BDR2-BD1 (unknown origin) by TR-FRET assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939296

Summary Related BioAssays by Target

Select item 193846116.

Binding affinity BRD2 (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1938461

Summary Related BioAssays by Target

Select item 193312517.

Binding affinity to BRD2 BD1 (unknown origin) assessed as change in melting temperature at 200 uM incubated for 30 to 60 mins by SYPRO orange dye based thermal shift assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:2 Tested

AID:: 1933125

Summary Related BioAssays by Target

Select item 192926418.

Binding affinity to BRD2 BD2 (unknown origin) by BROMOscan assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1929264

Summary Related BioAssays by Target

Select item 192926319.

Binding affinity to BRD2 BD1 (unknown origin) by BROMOscan assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1929263

Summary Related BioAssays by Target

Select item 192925820.

Inhibition of BRD2 BD1 (unknown origin) using biotinylated tetra-acetylated Histone H4 peptide as substrate and measured for 1 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: Bromodomain-containing protein 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1929258

Summary Related BioAssays by Target

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Target

Proteins (2)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (236)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (16)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (192)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (290)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (442)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (395)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (88)
BioAssays deposited by other experimentalists

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