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Inhibition of human RSK2 at 1 uM by radiometric assay in presence of ATP
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RSK2 in human MCF7 cells assessed as reduction of PMA-induced decrease in EF2 kinase phosphorylation at 25 uM pretreated for 24 hrs prior to PMA addition measured after 20 mins by immunoblot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of RSK2 in human MCF7 cells assessed as reduction of PMA-induced decrease in EF2 kinase phosphorylation at 100 uM pretreated for 2 hrs prior to PMA addition measured after 20 mins by immunoblot analysis
Inhibition of RSK2 in human PMA-stimulated MCF7 cells assessed as decrease in expression of 27kDa protein harboring (Lys/Arg)X(Lys/Arg)XX(pSer/pThr) motif at 25 uM pretreated for 24 hrs prior to PMA addition measured after 20 mins immunoblot analysis
Inhibition of RSK2 in human PMA-stimulated MCF7 cells assessed as decrease in expression of 27kDa protein harboring (Lys/Arg)X(Lys/Arg)XX(pSer/pThr) motif at 100 uM pretreated for 2 hrs prior to PMA addition measured after 20 mins by immunoblot analysis
AT1R-EGFR transactivation kinome screen - primary
Assay data:50 Active, 714 Tested
SummaryPubMed Citation
Millipore: Percentage of residual kinase activity of RPS6KA3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA
Assay data:158 Tested
Millipore: Percentage of residual kinase activity of RPS6KA3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA
Inhibition of RSK2 transfected in HEK293 cells
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Ratio of SL0101 IC50 to compound IC50 for recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells by chemiluminescence analysis
Inhibition of recombinant RSK2 after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of RSK2 assessed as residual activity at 10 uM
Inhibition of RSK2 assessed as residual activity at 1 uM
Inhibition of RPS6KA3
Inhibition of RSK2 N-terminal domain 1 assessed as residual activity at 10 uM relative to control
Inhibition of RSK2 C-terminal domain 2 assessed as residual activity at 10 uM relative to control
Inhibition of RSK2 using fluorescent labelled substrate at 5 uM by caliper method
Assay data:2 Tested
Inhibition of human RSK2 at 10 uM
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
Assay data:8 Active, 5 Activity ≤ 1 µM, 8 Tested
Inhibition of RSK2 (unknown origin) at 1 uM
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