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Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux
Assay data:34 Active, 1 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of bradykinin B1 receptor at 1 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]DAKA from human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at human bradykinin B1 receptor in IL1-beta stimulated IMR90 cells by FLIPR assay
Assay data:35 Active, 1 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 39 Tested
Receptor occupancy ex vivo in human BK B1 receptor expressed in transgenic rat spinal cord at 6 mg/kg, iv after 30 mins
Receptor occupancy ex vivo in human BK B1 receptor expressed in transgenic rat brain at 6 mg/kg, iv after 30 mins
Receptor occupancy ex vivo in human BK B1 receptor expressed in transgenic rat spinal cord at 0.6 mg/kg, iv after 30 mins
Receptor occupancy ex vivo in human BK B1 receptor expressed in transgenic rat brain at 0.6 mg/kg, iv after 30 mins
Receptor occupancy ex vivo in human BK B1 receptor expressed in transgenic rat spinal cord at 0.06 mg/kg, iv after 30 mins
Receptor occupancy ex vivo in human BK B1 receptor expressed in transgenic rat brain at 0.06 mg/kg, iv after 30 mins
Antagonist activity in human bradykinin B1 receptor by FLIPR method
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity at human bradykinin B1 receptor
Assay data:16 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 16 Tested
Binding affinity to human BK1 receptor
Assay data:17 Active, 4 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells
Assay data:34 Active, 2 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 35 Tested
Antagonist activity at bradykinin B1 receptor expressed in CHO cells assessed as inhibition of des-arg10-kallidin-induced increase in cytosolic calcium level by FLIPR assay
Assay data:7 Active, 4 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 10 Tested
Displacement of [3H]des-arg10, leu9-kallidin from human bradykinin B1 receptor expressed in CHO cells
Assay data:11 Active, 6 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Binding affinity to human bradykinin B1 receptor
Assay data:34 Active, 34 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical vein
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells
Assay data:12 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 13 Tested
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