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Displacement of [3H]ryanodine from wild type RyR2 (unknown origin) stably expressed in HEK293 cells microsomes at 10 uM by radioligand binding assay
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of wild type RyR2 (unknown origin) stably expressed in HEK293 cells coexpressing R-CEPIA1er assessed as Ca2+ leakage from ER at 10 uM compound addition at 100 secs and measured every 10 secs for 300 secs by fluorometric analysis
Assay data:3 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human RyR2 (Ryanodine receptors)
Assay data:8 Active, 8 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Induction of calstabin-2 binding to RyR2 P2328S mutant (unknown origin) at 0.1 umol/L
Assay data:1 Active, 1 Tested
Effect on baseline channel function of RyR2 (unknown origin) at 0.1 umol/L
Assay data:1 Tested
SummaryRelated BioAssays by Target
Effect on baseline channel function of RyR2 P2328S mutant (unknown origin) at 0.1 umol/L
Induction of normalization of single channel closed state of wild type PKA phosphorylated RyR2 (unknown origin) assessed as channel open probability at 0.1 umol/L relative to control
Induction of normalization of single channel closed state of PKA phosphorylated RyR2 P2328S mutant (unknown origin) assessed as channel open probability level at 0.1 umol/L (Rvb = 14.4%)
Induction of FKBP12.6 re-binding to PKA-phosphorylated-RyR2 (unknown origin) at 10 to 1000 nM after 30 mins in presence of [35S]-FKBP12.6 by liquid scintillation counting
Assay data:1 Active, 2 Tested
Induction of FKBP12.6 re-binding to PKA-phosphorylated-RyR2 (unknown origin) after 30 mins in presence of [35S]-FKBP12.6 by liquid scintillation counting
Assay data:52 Active, 52 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
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