BioAssay by Target (List) for Gene (Select 6326) - PubChem BioAssay - NCBI

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Select item 7262901.

Inhibition of voltage-gated Na channel 1.2 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:1 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 726290

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 11293082.

Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:2 Tested

AID:: 1129308

Summary PubMed Citation Related BioAssays by Target

Select item 11293073.

Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:2 Tested

AID:: 1129307

Summary PubMed Citation Related BioAssays by Target

Select item 11173574.

InfectX: Pathogen infection siRNA screens

Source:: InfectX Consortium

Assay data:115372 Tested

AID:: 1117357

Summary PubMed Citation

Select item 11172815.

A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:555 Active, 64752 Tested

AID:: 1117281

Summary PubMed Citation

Select item 11141816.

Binding affinity to Nav 1.2 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:12 Tested

AID:: 1114181

Summary Related BioAssays by Target

Select item 7679887.

Inhibition of NaV1.2 channel (unknown origin) at 0.1 uM by electrophysiology

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:3 Tested

AID:: 767988

Summary PubMed Citation Related BioAssays by Target

Select item 7679878.

Inhibition of NaV1.2 channel (unknown origin) at 1 uM by electrophysiology

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:3 Tested

AID:: 767987

Summary PubMed Citation Related BioAssays by Target

Select item 7679869.

Inhibition of NaV1.2 channel (unknown origin) at 10 uM by electrophysiology

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:3 Tested

AID:: 767986

Summary PubMed Citation Related BioAssays by Target

Select item 76798510.

Inhibition of NaV1.2 channel (unknown origin) at 100 uM by electrophysiology

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:3 Tested

AID:: 767985

Summary PubMed Citation Related BioAssays by Target

Select item 76659211.

Inhibition of human voltage-gated sodium channel subunit alpha Nav1.2 expressed in CHO cells by patch clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:2 Active, 2 Tested

AID:: 766592

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 74345412.

RNAi screen for vorinostat resistance genes - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:450 Active, 18118 Tested

AID:: 743454

Summary PubMed Citation

Select item 74312113.

Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:167 Active, 26449 Tested

AID:: 743121

Select item 112930914.

Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:1 Active, 2 Tested

AID:: 1129309

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 72627515.

Inhibition of human voltage-gated Na channel 1.2 by cell based patch clamp technique

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:1 Tested

AID:: 726275

Summary PubMed Citation Related BioAssays by Target

Select item 70002016.

Inhibition of human NaV1.2 alpha subunit expressed in CHOK1 cells at -65 mV holding potential by patch clamp electrophysiological assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:3 Active, 7 Tested

AID:: 700020

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 69096617.

Inhibition of human NaV1.2-mediated current at 10 uM

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:2 Tested

AID:: 690966

Summary PubMed Citation Related BioAssays by Target

Select item 67811518.

Inhibition of human NaV1.2 expressed in HEK293 cells at 10 uM using sodium currents elicited through depolarizing step from holding potential of -100 mV to +10 mV for 25 ms at 15 s intervals by whole cell patch clamp method

Source:: ChEMBL

Protein Target:: Sodium channel protein type 2 subunit alpha

Assay data:3 Tested

AID:: 678115

Summary PubMed Citation Related BioAssays by Target

Select item 65181119.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:9227 Active, 64752 Tested

AID:: 651811

Summary PubMed Citation

Select item 65181020.

Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:826 Active, 18119 Tested

AID:: 651810

Summary PubMed Citation

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (79)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (6)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (42)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (98)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (180)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (161)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (31)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 6326) (193)
PubChem BioAssay
Taxonomy Links for Protein (Select 489338454) (1)
Taxonomy
txid115547[Organism] (5)
Structure
MULTISPECIES: D-serine ammonia-lyase [Bacillus]
MULTISPECIES: D-serine ammonia-lyase [Bacillus]
gi|490533910|ref|WP_004399082.1|

Protein
basic leucine zipper transcriptional factor ATF-like 2 isoform 1 [Homo sapiens]
basic leucine zipper transcriptional factor ATF-like 2 isoform 1 [Homo sapiens]
gi|45238854|ref|NP_612465.3|

Protein

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