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Inhibition of human Nav1.3 expressed in CHO cells at -120 mV holding potential by automated patch clamp electrophysiology recording
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Voltage-Clamp Assay from US Patent US9675591: "Methods for treating seizure disorders and pain"
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Radioligand Binding Assay from US Patent US9694002: "Substituted benzamides and methods of use thereof"
Assay data:572 Active, 5 Activity ≤ 1 nM, 546 Activity ≤ 1 µM, 574 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Na+ channel (site 2) CEREP ligand profiling
SummaryRelated BioAssays by Target
NA+/SITE2ATG Eurofins-Panlabs selectivity data (BI)
NA+/SITE2AG Eurofins-Panlabs selectivity data (BI)
Na+ channel CEREP ligand profiling
Na+ channel (site1) CEREP ligand profiling
Na+ channel (site 2) Ligand binding assay
Inhibition of NaV1.3 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp technique
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NaV1.3 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp technique
Inhibition of human Nav1.3 expressed in HEK293 cells up to 1 uM incubated for 30 mins by FLIPRTetra fluorescent membrane potential assay
Inhibition of human NaV1.3 at 100 uM
Assay data:2 Tested
Inhibition of human Nav1.3 expressed in HEK293 cells assessed as V1/2 of inactivation at 10 uM at -120 mV holding potential by 10 Hz frequency second pulse protocol based manual patch clamp assay relative to control
Inhibition of human Nav1.3 at resting state expressed in HEK293 cells at 10 uM at -120 mV holding potential by 10 Hz single pulse protocol based manual patch clamp assay relative to control
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