BioAssay by Target (List) for Gene (Select 6331) - PubChem BioAssay - NCBI

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Select item 19194191.

Sodium Influx Assay (In Vitro Assay) from US Patent US11639351: "Heteroaryl-substituted sulfonamide compounds and their use as therapeutic agents"

Source:: BindingDB

Protein Targets:: Sodium channel protein type 1 subunit alpha; ...
Total:: 3

Assay data:47 Active, 28 Activity ≤ 1 µM, 48 Tested

AID:: 1919419

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19103672.

Inhibition of human Nav1.5

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1910367

Summary PubMed Citation Related BioAssays by Target

Select item 19076063.

Inhibition of human Nav1.5 at 10 uM relative to control by Electrophysiological QPatch assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1907606

Summary PubMed Citation Related BioAssays by Target

Select item 18981384.

Inhibition of human Nav1.5 expressed in CHO cells by manual patch clamp method

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1898138

Summary PubMed Citation Related BioAssays by Target

Select item 18979445.

Inhibition of Nav1.5 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1897944

Summary PubMed Citation Related BioAssays by Target

Select item 18976336.

Inhibition of human NaV1.5 at 10 uM relative to control

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1897633

Summary PubMed Citation Related BioAssays by Target

Select item 18915707.

Inhibition of human Nav 1.5 expressed in HEK293 cells at -90 mV holding potential by Whole cell voltage clamp electrophysiology assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:3 Active, 1 Activity ≤ 1 µM, 20 Tested

AID:: 1891570

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18810618.

Inhibition of NaV1.5 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1881061

Summary PubMed Citation Related BioAssays by Target

Select item 18810169.

Inhibition of Nav1.5 (unknown origin) at 10 uM

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1881016

Summary PubMed Citation Related BioAssays by Target

Select item 187583110.

Inhibition of human Nav1.5 expressed in HEK293 cells at -120 mV holding potential by automated patch clamp electrophysiology recording

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1875831

Summary PubMed Citation Related BioAssays by Target

Select item 187580211.

Inhibition of recombinant human Nav1.5 expressed in CHO cells by whole cell voltage clamp electrophysiology recording

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Active, 1 Tested

AID:: 1875802

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 187579912.

Inhibition of human Nav1.5 expressed in HEK293 cells by whole cell patch clamp electrophysiology recording

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Activity ≤ 1 µM, 12 Tested

AID:: 1875799

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187511313.

Inhibition of Nav1.5 (unknown origin) expressed in CHO cells at 1 uM at -130 mV holding potential by whole-cell voltage clamp method

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1875113

Summary PubMed Citation Related BioAssays by Target

Select item 187433714.

Inhibition of human NaV1.5 channel

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:3 Tested

AID:: 1874337

Summary PubMed Citation Related BioAssays by Target

Select item 186993415.

Effect on human Nav1.5 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1869934

Summary PubMed Citation Related BioAssays by Target

Select item 186221116.

Inhibition of NaV 1.5 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:2 Tested

AID:: 1862211

Summary PubMed Citation Related BioAssays by Target

Select item 186123617.

Inhibition of Nav1.5 (unknown origin)

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:2 Tested

AID:: 1861236

Summary PubMed Citation Related BioAssays by Target

Select item 185760318.

Inhibition of NaV1.5 (unknown origin) cardiac ion channel at 100 uM by patch clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Tested

AID:: 1857603

Summary PubMed Citation Related BioAssays by Target

Select item 185759419.

Inhibition of NaV1.5 (unknown origin) cardiac ion channel by patch clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:1 Active, 1 Tested

AID:: 1857594

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 185327720.

Inhibition of human NaV1.5 expressed in HEK293 by PatchXpress automated patch clamp assay

Source:: ChEMBL

Protein Target:: Sodium channel protein type 5 subunit alpha

Assay data:2 Tested

AID:: 1853277

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (173)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (14)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (100)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (356)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (512)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (492)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (32)
BioAssays deposited by other experimentalists

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