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Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CCL2 in human PBMC assessed as reduction of cell migration into TNFalpha/IFNgamma-stimulated HMEC-1 cells at 50 uM after 4 hrs
Assay data:2 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of CCL2 in human PBMC assessed as reduction of cell adhesion to VCAM1-Fc at 50 uM by flow based adhesion assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of CCL2 in human THP1 cells assessed as effect on level of ERK1/2 phosphorylation at 50 uM after 5 mins by Western blot analysis
Assay data:2 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
SummaryPubMed Citation
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Displacement of [125I]-CCL2 from human CCR2 receptor expressed in human U2OS cell membranes
Assay data:22 Active, 21 Activity ≤ 1 µM, 22 Tested
Displacement of [125I]-CCL2 from human CCR2 receptor expressed in human U2OS cell membrane at 1 uM relative to control
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [125I]-CCL2 from human CCR2 receptor expressed in human U2OS cell membrane assessed as kinetic rate index at Ki by dual-point competition association assay relative to control
Assay data:15 Tested
Displacement of [125I]-CCL2 from human CCR2 receptor expressed in human U2OS cell membrane assessed as residence time
Assay data:7 Tested
Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes by saturation binding assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of CCL2 in human THP1 cells assessed as reduction of cell migration into TNFalpha/IFNgamma-stimulated HMEC-1 cells at 50 uM after 4 hrs
Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of radioligand
Displacement of [3H]INCB3344 from human CCR2 receptor expressed in human U2OS cell membranes assessed as association and dissociation of compound by competition association assay
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Summary
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Inhibition of MCP1-mediated human THP cell migration
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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