BioAssay by Target (List) for Gene (Select 64115) - PubChem BioAssay - NCBI

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Select item 19300791.

Inhibition of VISTA (unknown origin) incubated for 15 mins by LANCE Ultra TR-FRET assay

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1930079

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19300732.

Binding affinity to recombinant human His-tagged VISTA extracellular binding domain incubated for 30 mins by microscale thermophoresis analysis

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Tested

AID:: 1930073

Summary PubMed Citation Related BioAssays by Target

Select item 19300723.

Binding affinity to recombinant human VISTA ECD incubated for 2 hrs by ELISA assay

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Tested

AID:: 1930072

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19300714.

Binding affinity to recombinant human His-tagged VISTA ECD incubated for 2 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Tested

AID:: 1930071

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18561535.

Binding affinity to VISTA (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1856153

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18561526.

Inhibition of recombinant VISTA signalling pathway (unknown origin) at 10 uM by HTRF assay relative to control

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Tested

AID:: 1856152

Summary PubMed Citation Related BioAssays by Target

Select item 18561497.

Binding affinity to VISTA (unknown origin) assessed as dissociation constant by MST method

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1856149

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18561488.

Inhibition of VISTA (unknown origin)

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1856148

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18561469.

Inhibition of VISTA (unknown origin) by ELISA method

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Tested

AID:: 1856146

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 185614510.

Inhibition of VISTA in human PBMC

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1856145

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184575611.

Inhibition of VISTA (unknown origin)

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1845756

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 153336712.

Inhibition of VISTA signaling in human PBMC assessed as IFNgamma release at 100 nM after 30 mins by ELISA

Source:: ChEMBL

Protein Target:: V-type immunoglobulin domain-containing suppressor of T-cell activation

Assay data:2 Tested

AID:: 1533367

Summary PubMed Citation Related BioAssays by Target

Select item 150858813.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 122483014.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:2853 Active, 18113 Tested

AID:: 1224830

Summary Related BioAssays by Same Project

Select item 115958415.

A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:2442 Active, 18052 Tested

AID:: 1159584

Summary PubMed Citation

Select item 115957816.

A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:1034 Active, 18120 Tested

AID:: 1159578

Summary Related BioAssays by Depositor

Select item 115950617.

Identification of proteins required for the processing of the EWS-FLI1 nascent transcript

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:59220 Tested

AID:: 1159506

Select item 111735718.

InfectX: Pathogen infection siRNA screens

Source:: InfectX Consortium

Assay data:115372 Tested

AID:: 1117357

Summary PubMed Citation

Select item 111728119.

A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:555 Active, 64752 Tested

AID:: 1117281

Summary PubMed Citation

Select item 74345420.

RNAi screen for vorinostat resistance genes - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:450 Active, 18118 Tested

AID:: 743454

Summary PubMed Citation

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Target

RNAi Target, Active (3)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (9)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (6)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (10)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (8)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (12)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (10)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (12)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (9)
BioAssays deposited by other experimentalists

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