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Inhibition of SMYD3 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000221b SMYD3
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (SPR measurement) EUB0000221b SMYD3
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (ITC) EUB0000221b SMYD3
Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b SMYD3
Affinity Biochemical interaction (Scintillation proximity assay (SPA)) EUB0000221b SMYD3
Affinity Phenotypic Cellular interaction (Immunoblot (inhibition of MAP3K2 methylation in HeLa cells)) EUB0000221b SMYD3
Inhibition of human SMYD3 at 10 uM by radioisotope-based filter binding assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human C-terminal His-tagged SMYD3 (2 to 428 residues) expressed in Sf9 insect cells at 1 uM using 3H-SAM as a substrate relative to control
Inhibition of human recombinant C-terminal his-tagged SMYD3 (2 to 428 residues) expressed in sf9 insect cells at 50 uM in presence of [3H]-SAM by scintillation/filter plate assay relative to control
Inhibition of human recombinant C-terminal his-tagged SMYD3 (2 to 428 residues) expressed in sf9 insect cells at 10 uM in presence of [3H]-SAM by scintillation/filter plate assay
Inhibition of SMYD3 (unknown origin) using p53 (361 to 380 residues) and [3H]-SAM as substrate incubated for 90 mins by SPA assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SMYD3 (unknown origin) at 1 to 10 uM
Assay data:2 Tested
SMYD3 Enzyme Assays on MEKK2 Protein Substrate from US Patent US10669243: "Isoxazole carboxamides as irreversible SMYD inhibitors"
Assay data:2 Active, 10 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
SMYD3 Biochemical Assay from US Patent US10577363: "Substituted piperidine compounds"
Assay data:860 Active, 14 Activity ≤ 1 nM, 620 Activity ≤ 1 µM, 980 Tested
HMT Assay from Article 10.1038/nchembio.2304: "An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
SMYD3 Biochemical Assay from US Patent US10266526: "Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer"
Assay data:107 Active, 8 Activity ≤ 1 nM, 75 Activity ≤ 1 µM, 629 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
SMYD3 biochemical assay from US Patent US10179773: "Isoxazole carboxamides as irreversible SMYD inhibitors"
SMYD3 Biochemical Assay from US Patent US10106510: "Substituted isoxazoles for treating cancer"
Assay data:47 Active, 23 Activity ≤ 1 µM, 59 Tested
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