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Activation of PINK1 in human HeLa MKYP PINK1-knock out cells at 3.125 to 6.25 uM assessed as reduction in pS129 alpha-synuclein
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activation of PINK1 in human iPSC derived neurons at 3.1 to 6.2 uM assessed as reduction in pS129 alpha-synuclein
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Activation of PINK1 in human HeLa MKYP PINK1-knock out cells treated with FCCP/oilgomycin assessed as increase in parkin recruitment and measured by ELISA assay
Activation of PINK1 in human HeLa MKYP cells expressing PINK1 treated with FCCP/oilgomycin assessed as increase in parkin recruitment and measured by ELISA assay
Activation of PINK1 in human HeLa MKYP PINK1-knock out cells treated with FCCP/oilgomycin assessed as increase in pS65 Ub and measured by ELISA assay
Activation of PINK1 in human HeLa MKYP cells expressing PINK1 treated with FCCP/oilgomycin assessed as increase in pS65 Ub and measured by ELISA assay
Activation of PINK1 in human HeLa cells stably expressing YFP parkin assessed as reduction in dOTC protein accumulation and measured by ornithine carbamoyltransferase (DOTC) assay relative to control
PINK1(PIN1PHRE) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressed with wild-type Parkin assessed as Parkin Ser65 phosphorylation at 10 uM by immunoblotting analysis
SummaryPubMed CitationRelated BioAssays by Target
Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressed with Parkin S65A mutant assessed as Parkin phosphorylation at 50 uM in absence of CCCP by immunoblotting analysis
Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressing wild-type Parkin assessed as Parkin Ser65 phosphorylation at 50 uM in absence of CCCP by immunoblotting analysis
Activation of FLAG tagged PINK1 (unknown origin) expressed in Flp-In TRex HEK293 cells co-expressing wild-type Parkin assessed as Parkin Ser65 phosphorylation at 50 uM after 24 hrs in absence of CCCP by immunoblotting analysis
Assay data:4 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human PINK assessed as residual activity at 1 uM in presence of [33P]ATP by filter binding assay relative to control
Primary screen of kinases in signalling pathway between Protease activated receptor 2 (PAR2) and the ion channels Transient receptor potential vanilloid-4 (TRPV4) in HEK293 cells
Assay data:91 Active, 714 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SW620)
Assay data:15 Active, 794 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC5)
Assay data:11 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Secondary Screen (DIFI)
Assay data:96 Active, 160 Tested
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