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Biosensor transport assay for SLC1A2 using HEK293-SLC1A2-WTOE cells
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Activation of human EAAT2 expressed in rat Astrocytes assessed as glutamate uptake by ELISA
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of human EAAT2 expressed in COS cells assessed as glutamate uptake
Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assay
Assay data:6 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 7 Tested
Activation of wild type human EAAT2 transfected in Glial cells assessed as glutamate uptake by measuring Km at 100 nM preincubated for 10 mins followed by L-glutamate addition and measured after 10 mins (Rvb = 9.1 +/- 3.9 microM)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of wild type human EAAT2 transfected in Glial cells assessed as glutamate uptake by measuring Km at 10 nM preincubated for 10 mins followed by L-glutamate addition and measured after 10 mins (Rvb = 9.1 +/- 3.9 microM)
Activation of wild type human EAAT2 transfected in Glial cells assessed as glutamate uptake by measuring Vmax at 100 nM preincubated for 10 mins followed by L-glutamate addition and measured per well after 10 mins (Rvb = 19.4 +/- 0.5 pmol/min)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of wild type human EAAT2 transfected in Glial cells assessed as glutamate uptake by measuring Vmax at 10 nM preincubated for 10 mins followed by L-glutamate addition and measured per well after 10 mins (Rvb = 19.4 +/- 0.5 pmol/min)
Activation of human EAAT2 transfected in Glial cells assessed as glutamate uptake
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Activation of human EAAT2 transfected in Glial cells assessed as glutamate uptake relative to control
Assay data:2 Tested
Activation of wild type human EAAT2 transfected in COS7 cells assessed as glutamate uptake by measuring Km at 100 nM preincubated for 10 mins followed by L-glutamate addition and measured after 10 mins (Rvb = 75 +/- 8 microM)
Activation of wild type human EAAT2 transfected in COS7 cells assessed as glutamate uptake by measuring Km at 10 nM preincubated for 10 mins followed by L-glutamate addition and measured after 10 mins (Rvb = 75 +/- 8 microM)
Activation of wild type human EAAT2 transfected in COS7 cells assessed as glutamate uptake by measuring Vmax at 100 nM preincubated for 10 mins followed by L-glutamate addition and measured per well after 10 mins (Rvb = 277 +/- 21 pmol/min)
Activation of wild type human EAAT2 transfected in COS7 cells assessed as glutamate uptake by measuring Vmax at 10 nM preincubated for 10 mins followed by L-glutamate addition and measured per well after 10 mins (Rvb = 277 +/- 21 pmol/min)
Activation of human EAAT2 transfected in COS7 cells assessed as glutamate uptake
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Activation of human EAAT2 transfected in COS7 cells assessed as glutamate uptake relative to control
Inhibition of human EAAT2 transfected in mouse C17.2 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 5 mins by liquid scintillation counting analysis
Inhibition of human EAAT2 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillation counting analysis
Assay data:5 Active, 2 Activity ≤ 1 µM, 6 Tested
Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 5 mins by liquid scintillation counting method
Assay data:37 Tested
Inhibition of human EAAT2 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake at 10 uM incubated for 5 mins by liquid scintillation counting method
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