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Substrate activity at PEPT1 in human Caco-2 cells assessed as reduction in drug uptake in presence of Gly-Sar by UPLC-MS/MS analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at PEPT1 in human Caco-2 cells assessed as fold reduction in drug uptake in presence of Gly-Sar by UPLC-MS/MS analysis relative to its enantiomers
Assay data:5 Tested
Substrate activity at PEPT1 in human Caco-2 cells assessed as fold increase in drug uptake by UPLC-MS/MS analysis relative to its enantiomers
Substrate activity at PEPT1 in human Caco-2 cells assessed as inhibition of Gly-Sar substrate uptake by UPLC-MS/MS analysis
Assay data:8 Tested
Substrate activity at PEPT1 (unknown origin) expressed in MDCK cells assessed as PEPT1 mediated drug uptake at 0.5 mM incubated for 10 mins by HPLC analysis
Assay data:10 Tested
Substrate activity at PEPT1 (unknown origin) expressed in MDCK cells assessed as inhibition of gly-sar uptake incubated for 10 mins by HPLC/MS/MS analysis
Substrate activity at PEPT1 in human Caco2 cells assessed as inhibition of Gly-Sar uptake by LC-MS/MS analysis
Assay data:2 Tested
Substrate activity at PEPT1 in human Caco2 cells assessed as inhibition of Gly-Sar uptake measured after 10 mins by UPLC-MS/MS analysis
Substrate activity at PEPT1 in human Caco2 cells assessed as Km measured after 10 mins by Eadie-Hofstee plot analysis
Substrate activity at PEPT1 in human Caco2 cells assessed as protein-mediated drug uptake at 0.5 mM measured after 10 mins in pH 6 HBSS buffer in presence of non-metabolized PEPT1 substrate Gly-Sar by UPLC-MS/MS analysis
Substrate activity at PEPT1 in human Caco2 cells assessed as protein-mediated drug uptake at 0.5 mM measured after 10 mins in pH 7.4 HBSS buffer by UPLC-MS/MS analysis
Substrate activity at PEPT1 in human Caco2 cells assessed as protein-mediated drug uptake at 0.5 mM measured after 10 mins in pH 6 HBSS buffer by UPLC-MS/MS analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Substrate activity at PepT1 in human Caco2 cells assessed as apparent permeability form apical to basolateral side at 2 mM in presence of Gly-Gln after 1 hr by HPLC analysis
Ratio of substrate activity of FSA to compound at PepT1 in human Caco2 cells assessed as apparent permeability form apical to basolateral side at 2 mM in presence of Gly-Gln after 1 hr by HPLC analysis
Assay data:9 Tested
Human Peptide transporter 1 (SLC15 family of peptide transporters)
Assay data:6 Active, 6 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Drug uptake in Pichia pastoris GS115 expressing human recombinant PEPT1 at 5 uM after 30s by dual-channel liquid scintillation counting analysis in presence of valacyclovir relative to control
Assay data:1 Tested
Drug uptake in Pichia pastoris GS115 expressing human recombinant PEPT1 at 5 uM after 30s by dual-channel liquid scintillation counting analysis in presence of acyclovir relative to control
Drug uptake in Pichia pastoris GS115 expressing human recombinant PEPT1 at 5 uM after 30s by dual-channel liquid scintillation counting analysis in presence of cephapirin relative to control
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