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Inhibition of human GFP-tagged ASM expressed in dog MDCK cells using sphingomyelin as substrate at 5 uM incubated for 48 hrs by Amplex Red dye based fluorescence analysis
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ASM (unknown origin)-mediated KRAS mislocalization from plasma membrane
Assay data:1 Active, 1 Tested
Inhibition of acid sphingomyelinase (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human acid sphingomyelinase (His62 to Pro628 residues) using NBD-sphingomyelin as substrate after 30 mins by fluorescence based assay
Assay data:10 Active, 2 Activity ≤ 1 µM, 10 Tested
Inhibition of human Huh7 cell derived acid sphingomyelinase using NBD-sphingomyelin as substrate after 30 mins by fluorescence based assay
Assay data:14 Active, 5 Activity ≤ 1 µM, 29 Tested
Inhibition of human full length ASM at 1 to 10 uM using HMU-PC as fluorogenic substrate incubated for 45 mins by fluorescence based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Competitive inhibition of acid sphingomyelinase in human HuH7 cell lysate using varying levels of NBD-sphingomyelin as substrate at 0.5 to 5 uM after 30 mins by Lineweaver-Burk analysis
Inhibition of acid sphingomyelinase in human HuH7 cell lysate using NBD-sphingomyelin as substrate after 30 mins by TLC based fluorescence assay
Assay data:15 Active, 8 Activity ≤ 1 µM, 48 Tested
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates at 100 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay
Assay data:2 Active, 2 Tested
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates at 0.5 to 50 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates up to 10 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates preincubated with compound followed by mmLDL stimulation by YO-PRO-1/Hoechst 33342 staining based assay
Inhibition of TNFalpha-stimulated acid sphingomyelinase in human PBMC lysates at 2 to 50 uM preincubated for 30 mins followed by TNFalpha stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates at 2 to 50 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates up to 2 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates assessed as enzyme residual activity at 25 uM using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method
Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method
Assay data:7 Active, 50 Tested
Inhibition of recombinant human acid sphingomyelinase expressed in HEKfreestyle293 cells using bodipy-C12 sphingomyelin as substrate and nanomolar to low micromolar concentration of compound after 1 hr by fluorescence assay
Assay data:63 Active, 63 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
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