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Invivo inhibition of STAT3 in BALB/c mouse xenografted with human MGC-803 cells assessed as reduction of Mcl-1 expression in tumor at 15 mg/kg,ip administrated for 21 consecutive days by immunohistochemistry analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Invivo inhibition of STAT3 in BALB/c mouse xenografted with human MGC-803 cells assessed as reduction of Mcl-1 expression in tumor at 5 mg/kg,ip administrated for 21 consecutive days by immunohistochemistry analysis
Invivo inhibition of STAT3 in BALB/c mouse xenografted with human MGC-803 cells assessed as reduction of c-Myc expression in tumor at 15 mg/kg,ip administrated for 21 consecutive days by immunohistochemistry analysis
Invivo inhibition of STAT3 in BALB/c mouse xenografted with human MGC-803 cells assessed as reduction of c-Myc expression in tumor at 5 mg/kg,ip administrated for 21 consecutive days by immunohistochemistry analysis
Invivo inhibition of STAT3 in BALB/c mouse xenografted with human MGC-803 cells assessed as reduction of STAT3 phosphorylation level at Tyr705 in tumor at 15 mg/kg,ip administrated for 21 consecutive days by immunohistochemistry analysis
Invivo inhibition of STAT3 in BALB/c mouse xenografted with human MGC-803 cells assessed as reduction of STAT3 phosphorylation level at Tyr705 in tumor at 5 mg/kg,ip administrated for 21 consecutive days by immunohistochemistry analysis
Inhibition of STAT3 in human AGS cells assessed as reduction of Mcl-1 protein expression level at 0.3 to 3 uM by western blot assay
Inhibition of STAT3 in human AGS cells assessed as reduction of c-Myc protein expression level at 0.3 to 3 uM by western blot assay
Inhibition of Flag-tagged STAT3 (unknown origin) dimerization transfected in HEK293T cells at 0.3 to 3 uM incubated for 24 hrs followed by IL-6 stimulation and measured after 1 hr by immunoprecipitation assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HA-tagged STAT3 (unknown origin) dimerization transfected in HEK293T cells at 0.3 to 3 uM incubated for 24 hrs followed by IL-6 stimulation and measured after 1 hr by immunoprecipitation assay
Inhibition of STAT3 in human MGC-803 cells assessed as inhibition of total STAT3 protein level at 0.3 to 3 uM by western blot assay
Inhibition of STAT3 in human AGS cells assessed as inhibition of total STAT3 protein level at 0.3 to 3 uM by western blot assay
Inhibition of STAT3 in human MGC-803 cells assessed as inhibition of STAT3 phosphorylation level at Tyr705 at 0.3 to 3 uM by western blot assay
Inhibition of STAT3 in human AGS cells assessed as inhibition of STAT3 phosphorylation level at Tyr705 at 0.3 to 3 uM by western blot assay
Thermal stabilization of STAT3 in human AGS cells at 1 uM at 37 to 54 degreeC incubated for 1 hr by cellular thermal shift assay
Assay data:2 Active, 2 Tested
Inhibition of STAT3 (unknown origin) transcriptional signaling transfected in HEK293T cells at 3 uM incubated for 24 hrs by firefly luciferase gene reporter assay
Assay data:12 Active, 12 Tested
Inhibition of STAT3 phosphorylation a in human MOLM16 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of IL6-stimulated STAT3 signalling in human CD4+ T cells
Inhibition of IFN-alpha induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IFN-alpha stimulation and measured after 15 mins by flow cytometric analysis
Inhibition of GM-CSF induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by GM-CSF stimulation and measured after 15 mins by flow cytometric analysis
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