BioAssay by Target (List) for Gene (Select 6789) - PubChem BioAssay - NCBI

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Select item 19629621.

STK4 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1962962

Summary Related BioAssays by Target

Select item 19628582.

STK4 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1962858

Summary Related BioAssays by Target

Select item 19627663.

STK4 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1962766

Summary Related BioAssays by Target

Select item 19626674.

STK4 SGC Tm panel (DSF)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1962667

Summary Related BioAssays by Target

Select item 19488175.

Inhibition of STK4 (unknown origin)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1948817

Summary PubMed Citation Related BioAssays by Target

Select item 19486376.

Binding affinity to recombinant STK4 (unknown origin) assessed as dissociation constant by DSF assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1948637

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19486267.

Inhibition of recombinant STK4 (unknown origin) at 10 uM by DSF assay relative to staurosporine

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1948626

Summary PubMed Citation Related BioAssays by Target

Select item 19486158.

Binding affinity to recombinant STK4 (unknown origin) assessed as change in melting temperature at 10 uM by DSF assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1948615

Summary PubMed Citation Related BioAssays by Target

Select item 19348629.

Inhibition of human full length wild type MST1 expressed in mammalian system at 1 uM by KINOMEscan analysis relative to control

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1934862

Summary PubMed Citation Related BioAssays by Target

Select item 192287310.

Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:9 Active, 7 Activity ≤ 1 µM, 9 Tested

AID:: 1922873

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 191542311.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000285b STK4

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1915423

Summary Related BioAssays by Target

Select item 191542212.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000285b STK4

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1915422

Summary Related BioAssays by Target

Select item 191362613.

Selectivity interaction (Enzymatic assay) EUB0000178b STK4

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913626

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191362514.

Selectivity interaction (ELISA-based kinase assay (inhibition of MOB1a phosphorylation at 11.2 M ATP)) EUB0000178b STK4

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913625

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191308915.

Affinity Biochemical interaction (Competition binding assay (DiscoverX)) EUB0000178b STK4

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913089

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191267616.

Affinity Phenotypic Cellular interaction (Immunoblotting (phosphorylation of endogenous MOB1; LATS1/2; and YAP in human liver carcinoma (HepG2) cells)) EUB0000178b STK4

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1912676

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191260117.

Thermal Shift Assay. Domain: start/stop: M1-E311

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:27 Tested

AID:: 1912601

Summary Related BioAssays by Target

Select item 190152618.

Inhibition of human full length recombinant MST1 assessed as residual activity at 1 uM using KKSRGDYMTMQIG as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:1 Tested

AID:: 1901526

Summary PubMed Citation Related BioAssays by Target

Select item 190053019.

Inhibition of STK4 (MST1) (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:2 Tested

AID:: 1900530

Summary PubMed Citation Related BioAssays by Target

Select item 189509920.

Binding affinity to MST1 (unknown origin) assessed as change in melting temperature by thermal shift based DSF assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 4

Assay data:16 Tested

AID:: 1895099

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (44)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (5)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (36)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (50)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (235)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (45)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (3)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (188)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (88)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 6789) (280)
PubChem BioAssay
Gene Links for GEO Profiles (Select 131670487) (1)
Gene
RAB37 RAB37, member RAS oncogene family [Homo sapiens]
RAB37 RAB37, member RAS oncogene family [Homo sapiens]
Gene ID:326624

Gene
Gene Links for GEO Profiles (Select 131412486) (1)
Gene
FUCA2 alpha-L-fucosidase 2 [Homo sapiens]
FUCA2 alpha-L-fucosidase 2 [Homo sapiens]
Gene ID:2519

Gene

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