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Inhibition of C-terminal 6x-histidine tagged beta-catenin (138 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 DE3/N-terminally biotinylated human E-cadherin (824 to 877 residues) protein-protein interactions by Alpha-screen assay
Assay data:10 Tested
SummaryRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of TCF-4/beta catenin in human Tcf22C11 cells expressing Tcf-4/SV40 binding sites driving firefly luciferase reporter gene after 24 hrs by luminometer
Assay data:230 Active, 123 Activity ≤ 1 µM, 264 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of TCF-4/beta catenin in human Tcf33.13 cells expressing Tcf-4/SV40 binding sites driving firefly luciferase reporter gene after 24 hrs by luminometer
Assay data:239 Active, 148 Activity ≤ 1 µM, 264 Tested
Antagonist activity against TCF-4 ( 1 to 56 residues) (unknown origin) binding to beta-catenin armadillo repeat units (unknown origin) assessed as reduction in TCF4-beta-catenin binding at 50 uM at 20 degC by WaterLOGSY NMR screening method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TCF-4 ( 1 to 56 residues) (unknown origin) binding to beta-catenin/armadillo (unknown origin) at 50 uM by ITC assay relative to control
Assay data:1 Tested
Inhibition of TCF-4 ( 1 to 56 residues) (unknown origin) binding to beta-catenin/armadillo (unknown origin) assessed as dissociation constant by ITC assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of TCF-4 ( 1 to 56 residues) (unknown origin) binding to beta-catenin/armadillo (unknown origin) by ITC assay
Inhibition of TCF-4 ( 1 to 56 residues) (unknown origin) binding to beta-catenin/armadillo (unknown origin) at 50 uM by ITC assay
Assay data:39 Active, 39 Tested
Competitive inhibition of wild type beta-catenin (unknown origin) expressed in Escherichia coli BL21 DE3 interaction with N-terminally biotinylated human E-cadherin (824 to 887 residues) by alpha screen assay
SummaryPubMed CitationRelated BioAssays by Target
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SW620)
Assay data:15 Active, 794 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC5)
Assay data:11 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HCT15)
Assay data:18 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (CAR1)
Assay data:9 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HT55)
Assay data:20 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (RCM1)
Assay data:13 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HT29)
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC1)
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (LS513)
Assay data:16 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (NCIH630)
Assay data:17 Active, 794 Tested
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