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Inhibition of TDO (unknown origin) at 100 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human TDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins by RapidFire-Mass spectrometry
Assay data:4 Active, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TDO in human HEK cells
Assay data:2 Tested
Inhibition of human TDO expressed in human T-REx cells using L-tryptophan as substrate after 20 hrs
Assay data:14 Active, 28 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TDO (unknown origin) using L-tryptophan as substrate by spectrophotometric method
Assay data:7 Active, 8 Tested
Inhibition of TDO (unknown origin) at 200 uM using L-tryptophan as substrate by spectrophotometric method relative to control
Inhibition of TDO (unknown origin) at 100 uM using L-tryptophan as substrate by spectrophotometric method relative to control
Assay data:24 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human TDO2 using tryptophan as substrate after 22 mins by LC-MS/MS method
Inhibition of TDO (unknown origin)
Inhibition of TDO in human SW48 cells after 24 hrs by NFK green reagent based assay
Assay data:24 Active, 22 Activity ≤ 1 µM, 25 Tested
Inhibition of recombinant human TDO assessed as reduction in conversion of L-tryptophan to kynurenine by methylene blue dye based spectrometric method
Assay data:13 Tested
Inhibition of recombinant human TDO2 expressed in CHOK1 cells assessed as reduction in kynurenine formation using L-tryptophan as substrate measured after 2 hrs by LC/MS/MS analysis
Assay data:151 Active, 151 Activity ≤ 1 µM, 262 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant human TDO at 10 uM using L-Trp as substrate after 75 mins by UV absorption analysis
Assay data:15 Tested
Inhibition of recombinant human TDO using L-Trp as substrate after 75 mins by UV absorption analysis
Assay data:7 Active, 5 Activity ≤ 1 µM, 15 Tested
Inhibition of recombinant TDO (unknown origin) assessed as reduction in N-formylkynurenine formation using L-Tryptophan as substrate after 75 mins by UV absorption method
Assay data:4 Active, 12 Tested
Inhibition of recombinant TDO (unknown origin) assessed as reduction in N-formylkynurenine formation at 10 uM using L-Tryptophan as substrate after 75 mins by UV absorption method relative to control
Assay data:12 Tested
Competitive inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 1 mM substrate addition measured after 15 mins by RapidFire mass spectrometry based fluorescence assay
Assay data:2 Active, 2 Tested
Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2 mM substrate addition measured after 15 mins by RapidFire mass spectrometry based fluorescence assay
Assay data:18 Active, 11 Activity ≤ 1 µM, 30 Tested
Inhibition of human recombinant pEF6/V5-His-tagged TDO2 transfected in HEK293-EBNA cells using L-tryptophan as substrate by HPLC analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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