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LR2 Assays from US Patent US20240043395: "COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING"
Assay data:57 Active, 26 Activity ≤ 1 µM, 70 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding affinity to TLR2 (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at TLR2/TLR1 in mouse Macrophage cell line
Assay data:29 Active, 32 Activity ≤ 1 µM, 76 Tested
Agonist activity at TLR2/TLR1 in human THP-1 cells
Assay data:41 Active, 15 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 89 Tested
Agonist activity at TLR2 in HEK-Blue hTLR2 cells
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at TLR2/TLR1 (unknown origin)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at TLR2 (unknown origin)
Assay data:10 Active, 8 Activity ≤ 1 µM, 16 Tested
Agonist activity at human TLR2 transfected in HEK293 cells
Assay data:60 Active, 37 Activity ≤ 1 µM, 67 Tested
Agonist activity at human TLR2 transfected in HEK293 cells relative to control
Assay data:10 Active, 5 Activity ≤ 1 µM, 87 Tested
Agonist activity at TLR2/TLR6 (unknown origin) assessed as induction of IL-8 production relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at TLR2/TLR1 (unknown origin) assessed as induction of IL-8 production relative to control
Assay data:2 Tested
Agonist activity at TLR1/TLR2 in human THP-1 derived macrophages assessed as stimulation of TNF alpha release measured for 4 hrs by ELISA based assay relative to diprovocim-1
Assay data:80 Tested
Agonist activity at TLR1/TLR2 in human THP-1 derived macrophages assessed as stimulation of TNF alpha release measured for 4 hrs by ELISA based assay
Assay data:94 Active, 53 Activity ≤ 1 nM, 93 Activity ≤ 1 µM, 94 Tested
Antagonist activity at human TLR2 in HEK-Blue hTLR2 cells assessed as inhibition of Pam3CSK4-induced receptor activation at 0.1 to 100 uM preincubated with Pam3CSK4 followed by compound addition and measured 24 hrs by Quanti-Blue based SEAP reporter gene assay
Assay data:4 Tested
Antagonist activity at human TLR2 in HEK-Blue hTLR2 cells assessed as inhibition of Pam3CSK4-induced receptor activation preincubated with Pam3CSK4 followed by compound addition and measured 24 hrs by Quanti-Blue based SEAP reporter gene assay
Assay data:25 Active, 2 Activity ≤ 1 µM, 26 Tested
Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in TNF-alpha production at 0.1 ug/ml incubated for 24 hrs
Assay data:7 Active, 7 Tested
Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-10 production at 0.1 ug/ml incubated for 24 hrs
Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-6 production at 0.1 ug/ml incubated for 24 hrs
Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assay
Assay data:11 Active, 4 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 11 Tested
Agonist activity at TLR1/TLR2 in human THP-1 cells assessed as induction of TLR1/TLR2 dimerization at 20 uM incubated for 12 hrs by coimmunoprecipitation method
Assay data:1 Active, 1 Tested
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