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Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microplate reader analysis
Assay data:28 Active, 13 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Tryptophan Hydroxylase Activity from US Patent US11407763: "Tryptophan hydroxylase inhibitor and pharmaceutical composition including same"
Assay data:22 Active, 18 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzyme Activity Assay from US Patent US11028104: "Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same"
Assay data:42 Active, 39 Activity ≤ 1 µM, 42 Tested
In Vitro Enzyme Activity Assay from US Patent US10683309: "Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same"
In Vitro Enzyme Activity Assay from US Patent US10214530: "Xanthine derivatives, their use as a medicament, and pharmaceutical preparations comprising the same"
Assay data:48 Active, 39 Activity ≤ 1 µM, 57 Tested
Biochemical In Vitro Assay from US Patent US9765092: "Tricyclic piperidine compounds"
Assay data:442 Active, 442 Activity ≤ 1 µM, 442 Tested
Inhibition of Tryptophan hydroxylase 1 (unknown origin) incubated for 4 hrs by fluorescence based assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 12 Tested
Inhibition of Tryptophan hydroxylase 1 (unknown origin) at 10 uM incubated for 4 hrs by fluorescence based assay
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Tryptophan hydroxylase 1 (unknown origin) at 1 uM incubated for 4 hrs by fluorescence based assay
Assay data:25 Tested
Inhibition of Tryptophan hydroxylase 1 (unknown origin)
Assay data:1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of TPH1 (unknown origin)
Assay data:38 Active, 37 Activity ≤ 1 µM, 38 Tested
Human L-Tryptophan hydroxylase 1 (Amino acid hydroxylases)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay data:65 Active, 60 Activity ≤ 1 µM, 67 Tested
Inhibition of TPH1 (unknown origin) using L-tyrosine as substrate after 20 mins
Assay data:34 Active, 16 Activity ≤ 1 µM, 37 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
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