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Inhibition of GST-tagged human recombinant TXK (260 to 527 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of TXK (unknown origin) at 1 uM relative to control
Inhibition of TXK (unknown origin) at 500 nM relative to control
Inhibition of TXK (unknown origin)
Inhibition of human TXK preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human TXK at 1 uM by hotspot assay relative to control
Selectivity interaction (KinaseProfiler? (Millipore)) EUB0000640a TXK
Selectivity interaction (Z?-LYTE assay) EUB0000638a TXK
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a TXK
Affinity Phenotypic Cellular interaction (CellTiter-Glo Luminescent Cell Viability Assay (Promega; growth inhibitory activity in Rec-1 cells)) EUB0000646a TXK
Inhibition of TXK (unknown origin) at 0.3 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TXK (unknown origin) at 0.5 uM assessed as competition rate relative to control
Inhibition of TXK (unknown origin) at 0.5 uM relative to control
Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysis
Assay data:5 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of Txk (unknown origin) at 1 uM relative to control
Inhibition of RLK (unknown origin) using peptide substrate in presence of ATP
Displacement of competitive tracer from RLK (unknown origin) assessed as target occupancy at 1.5 uM preincubated for 15 mins measured for 24 hrs relative to control
Displacement of competitive tracer from RLK (unknown origin) assessed as target occupancy at 1.5 uM preincubated for 15 mins measured for 6 hrs relative to control
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