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Agonist activity at VDR in human MCF7 cells assessed as upregulation of p27 expression at 10'-9 M after 48 hrs by Western blot method relative to control
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human VDR after 2 hrs by fluorescence assay relative to 1alpha,25(OH)2D3
Assay data:10 Tested
Reduction of VDR-mediated TRPV6 expression in human 1,25(OH)2D3-stimulated DU145 cells after 18 hrs by semiquantitative RT-PCR analysis
Assay data:1 Tested
Inhibition of VDR-LBD interaction to Alexa Fluor 647-labeled SRC2-3 pretreated with SRC2-3 for 3 hrs followed by addition of receptor measured after 5 mins by fluorescence polarization assay
Activation of VDR in human U87MG cells assessed as up-regulation of CYP24A1 at 10 uM by RT-PCR analysis relative to control
Assay data:7 Tested
Induction of vitamin D receptor-mediated differentiation of human HL60 cells at 10'-6 M by NBT reduction method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Transactivation of human VDR transfected in african green monkey COS7 cells after 24 hrs by luciferase reporter gene assay
Assay data:1 Active, 2 Tested
Transactivation of human VDR transfected in human SW480-ADH cells assessed as vitamin D response element-mediated transcriptional activity measured 48 hrs post infection by luciferase reporter gene assay
Assay data:2 Tested
Activation of VDR in human PBMC cells assessed as increase in 25-hydroxyvitamin D-24-hydroxylase mRNA expression at 100 pM by RT-PCR
Assay data:2 Active, 2 Tested
Displacement of [3H]1-alpha,25-(OH)2D3 from thymus VDR realtive to 1-alpha,25-(OH)2D3
Assay data:4 Tested
Effective concentration required for inhibition of Vitamin D3 receptor; No data
Assay data:3 Tested
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