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Surface Plasmon Resonance (SP1R) from US Patent US20230312542: "HYDROXYPYRROLIDINE DERIVATIVE AND MEDICINAL APPLICATION THEREOF"
Assay data:57 Active, 9 Activity ≤ 1 µM, 67 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorescence Polarization Assay (10% in DMSO) from US Patent US11512083: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:61 Active, 14 Activity ≤ 1 µM, 86 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Polarization Assay (1% in DMSO) from US Patent US11512083: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:90 Active, 40 Activity ≤ 1 µM, 136 Tested
Fluorescence Polarization Assay (0.25% in DMSO) from US Patent US11512083: "Compounds and methods for the enhanced degradation of targeted proteins"
Assay data:37 Active, 1 Activity ≤ 1 µM, 38 Tested
PROTAC activity at VHL/recombinant HMGCR in human Insig-depletion HepG2 cells assessed as degradation of HMGCR measured at 1 uM after 16 hrs relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/recombinant HMGCR in human Insig-depletion HepG2 cells assessed as degradation of HMGCR measured after 16 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/recombinant HMGCR in human HepG2 cells assessed as degradation of HMGCR measured at 0.1 uM after 16 hrs relative to control
PROTAC activity at VHL/HMGCR in human HepG2 cells assessed as degradation of HMGCR measured at 1 uM after 16 hrs relative to control
PROTAC activity at VHL/GPER (unknown origin) assessed as degradation of GPER
Assay data:2 Tested
PROTAC activity at VHL/ERalpha in human MCF7 cells assessed as degradation of ERalpha
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at VHL/AKT in human PC-3 cells assessed as reduction in total Akt level at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:16 Active, 26 Tested
PROTAC activity at VHL/KRAS G12C mutant in human NCI-H358 cells assessed as induction of KRAS G12C degradation by Western blot analysis
PROTAC activity at VHL/KRAS G12C mutant in human NCI-H23 cells assessed as induction of KRAS G12C degradation by Western blot analysis
PROTAC activity at VHL/KRAS G12C mutant in human SW1573 cells assessed as induction of KRAS G12C degradation by Western blot analysis
PROTAC activity at VHL/KRAS G12C mutant in human MIA PaCa-2 cells assessed as induction of KRAS G12C degradation by western blot analysis
PROTAC activity at VHL/KRAS G12C mutant in human NCI- H2030 cells assessed as induction of KRAS G12C degradation by western blot analysis
Binding affinity to human recombinant VHL assessed as dissociation constant by SPR assay
Assay data:2 Active, 3 Tested
PROTAC activity at VHL/BRD4 in human MV4-11 cells assessed as induction of BRD4 degradation measured after 24 hrs by western blot analysis
PROTAC activity at VHL/BRD4 in human MV4-11 cells assessed as induction of BRD4 degradation at 3 to 100 nM measured after 24 hrs by western blot analysis
Assay data:1 Active, 1 Tested
PROTAC activity at VHL/BRD4 in human MV4-11 cells assessed as induction of BRD4 degradation at 1 uM measured after 24 hrs by western blot analysis
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