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Binding affinity to ML-IAP in human SK-MEL-28 cells assessed as change in melting temperature at 10 uM incubated for 3 hrs followed by heating at 37 to 70 degree C for 3 mins by CETSA analysis (Rvb = 50 degreeC)
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal His-tagged wild type ML-IAP BIR domain (63 to 179 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inactivation constant using AVPIAQKSEK-biotinylated peptide as substrate incubated upto 40 mins by DELFIA assay
Assay data:1 Tested
Binding affinity to N-terminal His-tagged wild type ML-IAP BIR domain (63 to 179 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using AVPIAQKSEK-biotinylated peptide as substrate incubated upto 40 mins by DELFIA assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal His-tagged wild type ML-IAP BIR domain (63 to 179 residues) (unknown origin) expressed in Escherichia coli BL21 at protein:compound concentration ratio of 1:10 incubated for 2 hrs by SDS-PAGE analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal His-tagged wild type ML-IAP BIR domain (63 to 179 residues)(unknown origin) expressed in Escherichia coli BL21 at protein:compound concentration ratio of 1:2 incubated for 2 hrs by SDS-PAGE analysis
Antagonist activity at N-terminal His-tagged wild type ML-IAP BIR domain (63 to 179 residues)(unknown origin) expressed in Escherichia coli BL21 using AVPIAQKSEK-biotinylated peptide as substrate preincubated for 2 hrs with protein followed by substrate addition measured after 2 hrs by DELFIA assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at N-terminal His-tagged wild type ML-IAP BIR domain (63 to 179 residues) (unknown origin) expressed in Escherichia coli BL21 using AVPIAQKSEK-biotinylated peptide as substrate incubated for 2 hrs by DELFIA assay
Assay data:11 Active, 12 Activity ≤ 1 µM, 12 Tested
Binding affinity to N-terminal His-tagged wild type ML-IAP (63 to 179 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as change in melting temperature at 20 uM incubated for 2 hrs followed by heating at 40 to 70 degree C for 30 mins by SYPRO orange dye based thermal shift assay
Biological Assay from US Patent US11111270: "Inhibitor of apoptosis protein (IAP) antagonists"
Assay data:39 Tested
SummaryRelated BioAssays by Target
Biological Assays from US Patent US10300074: "Use of inhibitor of apoptosis protein (IAP) antagonists in HIV therapy"
Assay data:40 Tested
Fluorescence Polarization Affinity Measurements from Article 10.1021/jm801450c: "Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold."
Assay data:25 Active, 17 Activity ≤ 1 µM, 25 Tested
Fluorescence Polarization Affinity Measurements. from Article 10.1021/cb600276q: "Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs."
Assay data:6 Active, 5 Activity ≤ 1 µM, 7 Tested
Binding affinity to ML-IAP-BIR domain (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human baculoviral IAP repeat containing 7 (Inhibitors of apoptosis (IAP) protein family)
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Secondary Screen
Assay data:340 Active, 500 Tested
SummaryRelated BioAssays by Depositor
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
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