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Inhibition of LIN28A (unknown origin) by FRET assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of LIN28A cold shock domain (16 to 126 residues) (unknown origin) assessed as increase in thermal stability measured after 45 mins by differential scanning fluorimetry
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Lin28a/Lin28b in human paclitaxel-resistant JAR cells assessed as reduction in MDR1 expression at 40 uM measured after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of Lin28a/Lin28b in human paclitaxel-resistant JAR cells assessed as reduction in IMP1 expression at 40 uM measured after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human paclitaxel-resistant JAR cells assessed as potentiation of paclitaxel induced cytotoxicity at 40 uM pretreated for 30 hrs followed by paclitaxel addition and measured after 72 hrs by WTS assay
Inhibition of Lin28a/Lin28b in human paclitaxel-resistant JAR cells assessed as reduction in MDR1 expression at 10 uM measured after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human paclitaxel-resistant JAR cells assessed as reduction in IMP1 expression at 10 uM measured after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human paclitaxel-resistant JAR cells assessed as potentiation of paclitaxel induced cytotoxicity at 10 uM pretreated for 30 hrs followed by paclitaxel addition and measured after 72 hrs by WTS assay
Inhibition of Lin28a/Lin28b in human MCF7 cells assessed as reduction in Ras expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human MCF7 cells assessed as reduction in IMP1 expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human MCF7 cells assessed as reduction in HMGA2 expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a in human PA1 cells assessed as reduction in Lin28 expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a in human PA1 cells assessed as reduction in Ras expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a in human PA1 cells assessed as reduction in IMP1 expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a in human PA1 cells assessed as reduction in HMGA2 expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human JAR cells assessed as reduction in Lin28a expression at 5 to 10 uM after 24 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
Inhibition of Lin28a/Lin28b in human JAR cells assessed as reduction in Ras expression at 5 to 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human JAR cells assessed as reduction in IMP1 expression at 5 to 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human JAR cells assessed as reduction in HMGA2 expression at 5 to 10 uM after 24 hrs by Western blot analysis
Inhibition of Lin28a/Lin28b in human JAR cells assessed as reduction in HMGA2 expression after 24 hrs by dual-luciferase reporter gene assay
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