BioAssay by Target (List) for Gene (Select 815) - PubChem BioAssay - NCBI

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Select item 19408601.

Inhibition of CAMK2alpha (unknown origin) at 1000 nM relative to control

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Tested

AID:: 1940860

Summary PubMed Citation Related BioAssays by Target

Select item 19408592.

Inhibition of CAMK2alpha (unknown origin)

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1940859

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19099363.

Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin)

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested

AID:: 1909936

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19099134.

Binding affinity to recombinant human CaMK2alpha (345 to 475 residues) expressed in Escherichia coli BL21 DE3 assessed as thermal stability by measuring change in melting temperature at 0.625 to 160 uM by SYPRO orange dye based differential scanning fluorimetry

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Tested

AID:: 1909913

Summary PubMed Citation Related BioAssays by Target

Select item 19099125.

Binding affinity to recombinant human CaMK2alpha (345 to 475 residues) expressed in Escherichia coli BL21 DE3 assessed as thermal stability by measuring change in melting temperature at 160 uM by SYPRO orange dye based differential scanning fluorimetry

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Tested

AID:: 1909912

Summary PubMed Citation Related BioAssays by Target

Select item 19099116.

Binding affinity to recombinant human CaMK2alpha Phe467Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1909911

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19099107.

Binding affinity to recombinant human CaMK2alpha Ile464His mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1909910

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19099098.

Binding affinity to recombinant human CaMK2alpha Ile414Met mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1909909

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19099089.

Binding affinity to recombinant human CaMK2alpha Thr412Asn mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1909908

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190990710.

Binding affinity to recombinant human CaMK2alpha Glu355Gln mutant expressed in Escherichia coli BL21 DE3 assessed as dissociation constant by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1909907

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190990511.

Binding affinity to recombinant human CaMK2alpha Thr354Asn mutant expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by surface plasmon resonance assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1909905

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190990312.

Displacement of [3H]HOCPCA from recombinant full length CaMK2alpha (unknown origin) expressed in HEK293 cell homogenates assessed as inhibition constant measured after 60 mins by liquid scintillation counting method

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1909903

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189830313.

Inhibition of human CAMKIIalpha assessed as residual activity at 30 uM relative to control

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Tested

AID:: 1898303

Summary PubMed Citation Related BioAssays by Target

Select item 184899214.

Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as quenching of intrinsic tryptophan fluorescence at 9.8 to 29 uM by Trp flip assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Active, 1 Tested

AID:: 1848992

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 184899115.

Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as inhibition of intrinsic tryptophan fluorescence by Trp flip assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Active, 2 Tested

AID:: 1848991

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 184899016.

Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as internal absorbance at high concentrations by Trp flip assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Active, 1 Tested

AID:: 1848990

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 184898917.

Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as appearance of background fluorescence at 390 uM by Trp flip assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Active, 1 Tested

AID:: 1848989

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 184898818.

Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as internal absorbance at 800 uM by Trp flip assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Tested

AID:: 1848988

Summary PubMed Citation Related BioAssays by Target

Select item 184898719.

Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as appearance of background fluorescence at 800 uM by Trp flip assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Tested

AID:: 1848987

Summary PubMed Citation Related BioAssays by Target

Select item 184898620.

Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as change in apparent fluorescence at 800 uM by Trp flip assay

Source:: ChEMBL

Protein Target:: Calcium/calmodulin-dependent protein kinase type II subunit alpha

Assay data:1 Tested

AID:: 1848986

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (2)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (51)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (7)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (35)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (62)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (238)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (210)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (69)
BioAssays deposited by other experimentalists

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