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Inhibition of caspase-1 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of caspase 1 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of caspase 1 (unknown origin) assessed as enzyme residual activity using YVAD-AFC as substrate at 100 uM by fluorescence analysis
Assay data:33 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of caspase 1 (unknown origin) using YVAD-AFC as substrate by fluorescence analysis
Assay data:1 Tested
Inhibition of Caspase Activity Assay from US Patent US11447497: "(S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Caspase Catalytic Activity Assay from Article 10.1016/j.chembiol.2017.02.003: "Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors."
Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition Assay from Article 10.1111/cbdd.12572: "Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1."
Assay data:11 Active, 4 Activity ≤ 1 µM, 13 Tested
Fluorometric Enzymatic Assay from US Patent US9045524: "Selective caspase inhibitors and uses thereof"
Assay data:15 Active, 9 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Enzyme Inhibition Assay from Article 10.1021/jm900135r: "Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6."
Assay data:24 Active, 22 Activity ≤ 1 µM, 25 Tested
Caspase Inhibition Assay from Article 10.1016/s0960-894x(01)00573-x: "Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide."
Assay data:17 Active, 12 Activity ≤ 1 µM, 17 Tested
Caspase Inhibition Assay from Article 10.1016/s0968-0896(01)00250-4: "Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1)."
Assay data:9 Active, 1 Activity ≤ 1 µM, 13 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2003.10.064: "Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors."
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Caspase Inhibition Assay from Article 10.1016/j.bmcl.2005.05.116: "Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors."
Assay data:29 Active, 26 Activity ≤ 1 µM, 29 Tested
In Vitro Inhibitory Activity of Caspase from US Patent US10167313: "Selective caspase inhibitors and uses thereof"
Assay data:18 Active, 17 Activity ≤ 1 µM, 25 Tested
Caspase Inhibition Assay from Article 10.1021/jm0506625: "N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies."
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Caspase Inhibition Assay from Article 10.1021/jm0100537: "Potent and selective nonpeptide inhibitors of caspases 3 and 7."
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Fluorometric Assay from Article 10.1074/jbc.273.49.32608: "Inhibition of human caspases by peptide-based and macromolecular inhibitors."
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Fluorometric Assay from Article 10.1021/jm020230j: "Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design."
Assay data:42 Active, 34 Activity ≤ 1 µM, 43 Tested
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