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Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b SUV420H2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel) EUB0000196bCl SUV420H2
Selectivity interaction (Methyltransferase panel (radioactive enzyme assay)) EUB0000216b SUV420H2
Selectivity interaction (HMT panel) EUB0000194b SUV420H2
Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b SUV420H2
Affinity Biochemical interaction (Scintillation proximity assay (SPA)) EUB0000193b SUV420H2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Western Blot (decrease in di-methylation of H4K20me in U20S cells)) EUB0000193b SUV420H2
Inhibition of SUV420H2 (unknown origin) at 1 to 10 uM
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Scintillation Proximity Assay (SPA) from Article 10.1038/nchembio.2282: "The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity."
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SUV420H2 (unknown origin) using biotin-labeled histone substrate assessed as residual activity at 50 uM in presence of [3H-Me]SAM by scintillation proximity assay relative to control
Assay data:24 Tested
Inhibition of human SUV420H2 up to 50 uM using Biot-H4K20me1 as substrate and in presence of [3H]-SAM incubated for 1 hr by scintillation proximity assay
Inhibition of SUV420H2 in human MCF7 cells assessed as decrease in H4K20me3 level up to 50 uM measured after 2 days by immunoblot analysis
Inhibition of SUV420H2 (unknown origin) at 1 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SUV420H2 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of SUV420H2 (unknown origin) at 10 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
Human lysine methyltransferase 5C (2.1.1.43 Histone methyltransferases (HMTs))
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of SUV420H2 (unknown origin) at 50 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
Inhibition of SUV420H2 (unknown origin) at 1 to 50 uM by scintillation proximity assay
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