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Selectivity interaction (Kinase Panel (competition binding assay)) EUB0000589aTFA CDK13
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant N-terminal GST/His6-fusion tagged human CDK13/Cyclin K expressed in Sf9 insect cells incubated for 20 mins followed by [33P]gamma-ATP addition and measured after 2 hrs by radiometric HotSpot Kinase assay
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant CDK13 (unknown origin) expressed in baculovirus infected insect cells using Pol II CTD peptide as substrate in presence of [gamma-32P]ATP by radiometric kinase assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to partial length human wild-type CDK13 expressed in mammalian expression system assessed as dissociation constant by DiscoverX KINOMEscan assay
Binding affinity to CDK13 (unknown origin) assessed as dissociation constant
Inhibition of recombinant CDK13 (unknown origin) by radiometric kinase assay
Inhibition of GST-tagged human CDK13/Cyclin K expressed in Sf9 cells using RBER-IRStide peptide as substrate in presence of ATP and [gamma33-P] ATP by radioisotope filter binding assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as inhibition of degradation of CDK13 at 500 nM measured after 6 hrs presence of thalidomide
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as degradation of CDK13 at 500 nM measured after 6 hrs in presence of bafilomycin by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as degradation of CDK13 at 500 nM measured after 6 hrs in presence of carfilzomib by Western blot analysis
Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of degradation at 500 nM measured after 4 hrs by Western blotting analysis
Protac activity at CRBN/CDK13 in human MFM-223 cells assessed as induction of degradation at 500 nM measured after 4 hrs by Western blotting analysis
Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of degradation by Western blotting analysis
Protac activity at CRBN/CDK13 in human MFM-223 cells assessed as induction of degradation by Western blotting analysis
Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of CDK13 degradation incubated for 15 hrs by immunoblotting analysis
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Protac activity at CRBN/CDK13 in human MDA-MB-231 cells assessed as induction of CDK13 degradation at 1 uM incubated for 15 hrs by immunoblotting analysis relative to control
Assay data:27 Tested
Binding affinity to human CDK13 (694 to 1039 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interferometry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of CDK13 (unknown origin)
Irreversible inhibition of CDK13 (unknown origin)
Inhibition of recombinant CDK13/Cyclin K (unknown origin) expresssed in baculovirus infected insect cells using peptide substrate incubated for 30 mins in presence of [32P]gamma-ATP by scintillation counter method
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