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Antagonist activity at human LPA2 receptor assessed as inhibition of LPS-induced calcium release
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at LPA2 receptor (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of LPA2 receptor (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Binding affinity to LPA2 receptor (unknown origin) by free solution assay-compensated interferometric reader (FSA-CIR) technique
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at LPA2 receptor (unknown origin) expressed in cells assessed as calcium mobilization at 10 uM by Fluo-4 NW dye based assay
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at LPA2 receptor (unknown origin) expressed in cells assessed as maximal blockade of LPA-induced calcium mobilization at 10 uM measured after 120 secs by Fluo-4 NW dye based assay relative to control
Antagonist activity at LPA2 receptor (unknown origin) expressed in cells assessed as blockade of LPA-induced calcium mobilization measured after 120 secs by Fluo-4 NW dye based assay
Assay data:4 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
PRESTO-Tango GPCRome screening (LPAR2)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of LPA2 (unknown origin)
Inhibition of LPAR2 (unknown origin)
Agonist activity at human Flag-tagged LPA2 expressed in rat B103 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay
Agonist activity at LPA2 (unknown origin) by [35S]GTPgammaS binding assay
Assay data:1 Active, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Antagonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as inhibition of LPA-induced intracellular calcium level up to 100 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay
Assay data:5 Tested
Agonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level up to 10 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay
Assay data:3 Tested
Agonist activity at LPA2 receptor (unknown origin) expressed in MEF cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Antagonist activity at human LPA2 receptor expressed in rat B103 cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysis
Antagonist activity at human LPA2 receptor expressed in CHO cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysis
SummaryCompounds, ActiveRelated BioAssays by Target
Antagonist activity at human LPA2 receptor expressed in RH7777 cells assessed as inhibition of LPA-induced calcium mobilization by Fura-2 AM probe-based fluorometric analysis
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