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Inhibition of HDAC in human HCT-116 cells assessed as increase in histone H3 acetylation at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HDAC in human BT-549 cells assessed as increase in level of acetyl-H3K9/14 substrate at 3 uM incubated for 12 hrs by chemiluminescence based Western blotting analysis
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
HDAC Enzyme Inhibition Assay from Article 10.1021/jm800251w: "Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HDAC in human Cal27CisR cells assessed as combination index at 3 uM measured in presence of 10 uM cDDP by MTT-based Chou-Talalay method
Assay data:1 Tested
Inhibition of HDAC in human HepG2 cells assessed as acetylation of histone H3 at K9 at 10 uM incubated for 4 hrs followed by stimulation with 50 ng/ml growth factor EGF for 15 mins by Western blot analysis (Rvb = 2.1 %)
Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in acetyl histone H3 level at 5 to 10 uM after 12 hrs by Western blot analysis
Inhibition of HDAC in human HCT116 cells assessed as induction of autophagy at marginal level by measuring LC3-I cleavage to LC3-II at 10 uM measured after 24 hrs by Western blot analysis
Inhibition of human HDAC4 at 1 uM using Boc-Lys(trifluoroacetyl)-AMC substrate
Assay data:10 Tested
Inhibition of partially purified HDAC isolated from human M8 cells enzyme fraction pre-incubated for 5 mins before [3H]acetylated histone addition and measured after 30 mins by scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human HDAC in HeLa cell nuclear extract for 60 mins by HDAC-Glo 1/2 reagent based chemiluminescence analysis
Activation of HDAC4 using trifluoroacetyl-lysine containing fluorogenic substrate at 10 uM by spectrofluorometry
Assay data:15 Tested
Inhibition of human HDAC in HeLa cells by fluorescent activity assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of Class 1 HDAC in human Jurkat cells assessed as hyperacetylation of bulk histones AcH3K18 after 24 hrs by immunoblot method
Inhibition of HDAC in human HCT116 cells assessed as alpha-tubulin deacetylation
Assay data:2 Active, 6 Tested
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