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Selectivity interaction (KinomeScan (DiscoverX)) EUB0000586a TLK1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: D448-N746
Assay data:27 Tested
Inhibition of TLK1 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human full length recombinant TLK1 assessed as residual activity at 1 uM using casein as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full length GFP-tagged TLK1 (unknown origin) transfected in HEK293T cells at 50 uM using GST-ASF1a as substrate incubated for 30 mins by Western blot analysis
TLK1 DiscoveRx kinase panel
TLK1 SGC Tm panel (DSF)
TLK1(h) Kinase panel
Inhibition of TLK1 (unknown origin) at 1 uM
Inhibition of human recombinant TLK1 assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
KinomeScan assay: inhibition of TLK1
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
TLK1(TLK1LGP1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
TLK1(h) Eurofins kinase panel
TLK1(h) Eurofins Kinase panel
TLK1(h) Millipore kinase panel
TLK1 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of NanoLuc-fused TLK1 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assay
Assay data:2 Tested
Inhibition of wild-type human partial length TLK1 (K447 to A754 residues) expressed in bacterial expression system assessed as residual percent of control by Kinomescan method relative to control
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