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CCRIS carcinogenicity studies
Assay data:1139 Active, 1767 Tested
SummaryCompounds, Active
GENE-TOX mutagenicity studies
Assay data:1995 Active, 3214 Tested
CCRIS mutagenicity studies
Assay data:4929 Active, 8266 Tested
qHTS assay to identify small molecule antagonists of the estrogen related receptor signaling pathway with the pleiotropic PPARgamma coactivator (PGC) from Tox21 10K library: Summary
Assay data:462 Active, 149 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line in the presence of 0.1 nM 17-beta-estradiol: Summary
Assay data:581 Active, 153 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the constitutive androstane receptor (CAR) signaling pathway: Summary
Assay data:1090 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 40 hour
Assay data:1023 Active, 88 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Agonist activity at AHR in FVB/N mouse primary mammary epithelial cells assessed as upregulation of desmoglein-3 protein level at 10 nM after 144 hrs by Western blot analysis in presence of FGF2
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary
Assay data:1147 Active, 1 Activity ≤ 1 nM, 122 Activity ≤ 1 µM, 9305 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary
Assay data:1063 Active, 1 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary
Assay data:477 Active, 2 Activity ≤ 1 nM, 241 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway
Assay data:788 Active, 71 Activity ≤ 1 µM, 10486 Tested
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line
Assay data:477 Active, 4 Activity ≤ 1 nM, 279 Activity ≤ 1 µM, 10486 Tested
Agonist activity at Ah receptor in genetically engineered mouse cells expressing firefly luciferase gene by CALUX transactivational assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF)
Assay data:2 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 871 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Induction of CYP1B1 expression in human MCF7 cells at 10 nM after 24 hrs by 7-ethoxyresorufin-O-deethelase assay
SummaryCompounds, ActivePubMed Citation
Inhibition of CYP1B1
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Binding affinity of [125I]T4 to rat liver nuclear extract at a dose of 50 ug/Kg
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity of [125I]-T4 to rat liver nuclear extract at a dose of 37 ug/Kg
Binding affinity of [125I]T4 to rat liver nuclear extract at a dose of 25 ug/Kg
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