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Anticoagulant activity in human corn trypsin inhibitor citrated platelet poor plasma assessed as reduction of tissue factor-induced thrombin generation at 1 to 20 pM after 5 mins
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Anticoagulant activity in 20 pM tissue factor stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Anticoagulant activity in 10 pM tissue factor stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in 3 pM tissue factor stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Anticoagulant activity in 1 pM tissue factor stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in 0.3 pM tissue factor stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in 10 pM recombinant coagulation factor 11a stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in 3 pM recombinant coagulation factor 11a stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in 1 pM recombinant coagulation factor 11a stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in 0.3 pM recombinant coagulation factor 11a stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in 0.1 pM recombinant coagulation factor 11a stimulated human CTI-citrated plasma assessed as inhibition of thrombin generation incubated for 5 mins by calibrated automated thrombogram analysis
Anticoagulant activity in human plasma assessed as concentration required to double prothrombin time
Assay data:16 Active, 8 Activity ≤ 1 µM, 16 Tested
Inhibition of purified human factor Xa
Assay data:17 Active, 13 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Summary
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Antithrombotic activity in iv dosed rabbit assessed as restoration of integrated blood flow
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Antithrombotic activity in iv dosed rabbit assessed as reduction in thrombus weight measured per hr
Anticoagulant activity in human platelet assessed as concentration required to double prothrombin time
Assay data:39 Active, 1 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 40 Tested
Anticoagulant activity in human platelet assessed as concentration required to double activated partial prothrombin time
Assay data:17 Active, 12 Activity ≤ 1 µM, 18 Tested
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