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Bioluminescence Resonance Energy Transfer (BRET) Assay from US Patent US20240132519: "NRF2-ACTIVATING COMPOUND"
Assay data:35 Active, 24 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Endothelin ETB Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Bradykinin B2 Eurofins Panlabs panel
Angiotensin AT1 Eurofins Panlabs panel
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 20 Tested
Binding affinity towards human EDNRB in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 298 Tested
Binding affinity towards human BDKRB2 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:3 Active, 1096 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay data:26 Active, 5 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 1184 Tested
Inhibition of AKT1 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of AKT1 (unknown origin) in presence of ATP by ELISA
Assay data:4 Tested
Inhibition of calmodulin (unknown origin)
Assay data:2 Tested
Inhibition of AKT1 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
Binding affinity to HSP90 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in entropy by isothermal titration calorimetry assay
Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in enthalpy by isothermal titration calorimetry assay
Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in free energy by isothermal titration calorimetry assay
Inhibition of Nrf2-Keap1 Kelch domain (unknown origin) protein-protein interaction in presence of biotin labeled 16mer ETGE peptide AFFAQLQLDEETGEFL
Assay data:5 Active, 2 Activity ≤ 1 µM, 21 Tested
Inhibition of HDAC in human HeLa nuclear extract assessed as residual activity at 20 uM relative to control
Assay data:16 Tested
Inhibition of HDAC in human HCT-116 cells assessed as increase in alpha tubulin acetylation at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
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