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Antiviral activity against simian-human immunodeficiency virus 89.6P in infected rhesus macaques
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Plasma concentration in rhesus macaque at 10 mg/kg after 12 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against simian immunodeficiency virus
Half life in rhesus monkey at 10 mg/kg, po
Assay data:1 Tested
SummaryPubMed Citation
Bioavailability in rhesus monkey at 10 mg/kg, po
Plasma concentration in rat after 24 hrs
AUC in rat at 10 mg/kg, po
Oral bioavailability in rat at 10 mg/kg, po
Clearance in rat at 2 mg/kg, iv
Assay data:7 Tested
Protein binding in human plasma at pH 7.4
Assay data:12 Tested
Inhibition of HIV1 replication in MT4 cells in presence of 50% NHS
Assay data:10 Active, 10 Activity ≤ 1 µM, 12 Tested
Inhibition of HIV1 replication in MT4 cells in presence of 10% FBS
Assay data:12 Active, 11 Activity ≤ 1 µM, 12 Tested
Inhibition of strand transfer process of HIV1 integrase
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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