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Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as reduction in bacterial count in liver at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 6 hr
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as reduction in bacterial count in spleen at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 6 hr
Cmax in brain of Listeria monocytogenes EGD-e infected BALB/c mouse central nervous system listeriosis model at 50 mg/kg, ip administered 36 hrs postinfection as single dose
Assay data:1 Tested
SummaryPubMed Citation
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as mouse survival at 50 mg/kg, ip administered 36 hrs postinfection every 12 hrs for 5 days measured after 2 months
Assay data:2 Active, 2 Tested
Ratio of Cmax in plasma in Listeria monocytogenes EGD-e infected BALB/c mouse to MIC for Listeria monocytogenes EGD-e
Ratio of AUC (24 hrs) in plasma in Listeria monocytogenes EGD-e infected BALB/c mouse to MIC for Listeria monocytogenes EGD-e
Cmax in plasma in Listeria monocytogenes EGD-e infected BALB/c mouse central nervous system listeriosis model at 50 mg/kg, ip administered 36 hrs postinfection as single dose
AUC (24 hrs) in brain of Listeria monocytogenes EGD-e infected BALB/c mouse central nervous system listeriosis model at 50 mg/kg, ip administered 36 hrs postinfection as single dose
AUC (24 hrs) in plasma in Listeria monocytogenes EGD-e infected BALB/c mouse central nervous system listeriosis model at 50 mg/kg, ip administered 36 hrs postinfection as single dose
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as reduction in bacterial count in liver at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 1 hr
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as reduction in bacterial count in spleen at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 1 hr
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as log reduction in bacterial CFU in brain at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 1 hr
Assay data:2 Tested
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as log reduction in bacterial CFU per ml of blood at 50 mg/kg, ip administered 36 hrs postinfection as single dose measured within 1 hr
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as increase in mouse survival at 50 mg/kg, ip administered 36 hrs postinfection every 12 hrs for 5 days
Antibacterial activity against Listeria monocytogenes EGD-e in BALB/c mouse central nervous system listeriosis model assessed as increase in mouse survival at 50 mg/kg, ip administered 36 hrs postinfection as single dose
Drug level in human plasma at 400 mg/day after 8 hrs
Cmax in Nocardia brasiliensis HUJEG-1 infected BALB/c mouse at 25 mg/kg, sc every 8 hrs by HPLC
Assay data:1 Active, 2 Tested
Antimicrobial activity against Nocardia brasiliensis HUJEG-1 by broth microdilution method
Antibacterial activity against intracellular Listeria monocytogenes EGDe infected in bone marrow-derived BALB/c mouse macrophage assessed as reduction in the number of infected macrophages after 3 hrs
Antibacterial activity against intracellular Listeria monocytogenes EGDe infected in bone marrow-derived BALB/c mouse macrophage assessed as prevention of bacterial release and spread of infection by preventing macrophage lysis after 24 hrs
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