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Inhibition of Vif-mediated human A3G degradation in HEK-293T cells cotransfected with hA3G and Vif at 20 uM by western blot analysis relative to control
Assay data:22 Tested
SummaryPubMed CitationRelated BioAssays by Target
HIV Integrase Inhibitory Assay from US Patent US10065950: "Substituted thiazoles as HIV integrase inhibitors"
Assay data:353 Active, 353 Activity ≤ 1 µM, 353 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Reversal of HIV1 Vif mediated A3G degradation in HIV1 infected human H9 cells for 48 hrs by western blotting analysis
Assay data:1 Tested
Inhibition of HIV1 HA-tagged Vif expressed in HEK293T cells co-expressing Myc-tagged pcDNA-APOBEC3G and pcDNA-ubiquitin-His assessed as reduction in Vif-mediated A3G polyubiquitination at 3.5 to 35 nM measured after 48 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HIV1 HA-tagged Vif expressed in HEK293T cells co-expressing Myc-tagged pcDNA-APOBEC3G and pcDNA-ubiquitin-His assessed as reduction in Vif-mediated A3G polyubiquitination at 10 uM measured after 16 hrs by Western blot analysis
Inhibition of HIV1 HA-tagged Vif expressed in HEK293T cells co-expressing eGFP-tagged pcDNA-APOBEC3G assessed as reduction in Vif-mediated A3G degradation at 10000 nM measured after 48 hrs by flow cytometry
Inhibition of HIV1 HA-tagged Vif expressed in HEK293T cells co-expressing eGFP-tagged pcDNA-APOBEC3G assessed as reduction in Vif-mediated A3G degradation at 10 nM measured after 48 hrs by flow cytometry
Inhibition of HIV1 HA-tagged Vif expressed in HEK293T cells co-expressing Myc-tagged pcDNA-APOBEC3G assessed as reduction in Vif-mediated A3G degradation at 10000 nM measured after 48 hrs by Western blot analysis
Inhibition of HIV1 HA-tagged Vif expressed in HEK293T cells co-expressing Myc-tagged pcDNA-APOBEC3G assessed as reduction in Vif-mediated A3G degradation at 10 nM measured after 48 hrs by Western blot analysis
Inhibition of HIV1 HA-tagged Vif expressed in HEK293T cells co-expressing Myc-tagged pcDNA-APOBEC3G assessed as reduction in Vif-mediated A3G degradation at 10 uM measured after 16 hrs by Western blot analysis
Antagonist activity against HIV-1 Vif in human H9 cells expressing A3G assessed as inhibition of viral replication by reverse transcriptase assay relative to vehicle-treated control
Assay data:9 Tested
Antagonist activity against HIV-1 GFP-tagged Vif in human HEK293FT cells co-expressing HA-tagged A3G assessed as downregulation of Vif expression expression at 50 uM measured after 16 hrs by immunoblotting method
Assay data:12 Active, 12 Tested
Antagonist activity against HIV-1 GFP-tagged Vif in human HEK293FT cells co-expressing HA-tagged A3G assessed as upregulation of A3G levels at 50 uM measured after 16 hrs by immunoblotting method
Antagonist activity against HIV-1 Vif in human MT4 cells assessed as inhibition of viral infection measured after 16 hrs by cell-based assay
Assay data:2 Tested
Antagonist activity against HIV-1 Vif in human MT4 cells assessed as inhibition of viral infection at 50 uM measured after 16 hrs by cell-based assay
Assay data:88 Tested
Antagonist activity against HIV-1 Vif in human MT4 cells assessed as inhibition of viral infection at 50 and 100 uM measured after 16 hrs by cell-based assay
Antagonist activity against HIV-1 Vif in human H9 cells expressing A3G assessed as inhibition of viral infection measured after 16 hrs by cell-based assay
Assay data:36 Active, 10 Activity ≤ 1 µM, 41 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity against HIV-1 Vif in human CEM cells assessed as inhibition of viral infection
Inhibition of recombinant APOBEC3G C321A mutant (unknown origin) expressed in HEK293 cells assessed as reduction in cytosine deaminase activity using 5'-6-FAM and 3'-TAMRA quench molecule tagged cytosine-containing single-stranded DNA substrate incubated for 2 hrs by fluorescence-based assay
Assay data:8 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant APOBEC3A (unknown origin) expressed in HEK293 cells assessed as reduction in cytosine deaminase activity at 200 uM using 5'-6-FAM and 3'-TAMRA quench molecule tagged cytosine-containing single-stranded DNA substrate incubated for 2 hrs by fluorescence-based assay relative to control
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