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Inhibition of BBOX1 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human BBOX using GBBF as substrate in presence of 2OG and Fe2+ using TBS-protected fluorescein probe by fluoride release assay
Assay data:1 Active, 4 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity to human BBOX in presence of Fe(II) by tryptophan fluorescence quenching binding assay
Assay data:2 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to human BBOX by tryptophan fluorescence quenching binding assay
Assay data:3 Active, 8 Tested
Binding affinity to human BBOX assessed as covalent modification by measuring PhSe group mass shift at 10 equivalent dose after 24 hrs by non-denaturating LC-MS method
Assay data:1 Active, 1 Tested
Binding affinity to human BBOX assessed as covalent modification by measuring PhSe group mass shift at 1 equivalent dose after 24 hrs by LC-MS method
Binding affinity to human BBOX assessed as covalent modification by measuring PhSe group mass shift at 1 equivalent dose by LC-MS method
Assay data:3 Active, 3 Tested
Binding affinity to human BBOX assessed as quenching of intrinsic tryptophan fluorescence at 50 to 200 uM in absence of Fe(II)
Assay data:7 Active, 8 Tested
Binding affinity to human BBOX assessed as quenching of intrinsic tryptophan fluorescence at 50 to 200 uM in presence of Fe(II)
Assay data:5 Active, 5 Tested
Induction of Zn(II) from human BBOX assessed as zinc release by fluorescence based assay
Assay data:8 Tested
Inhibition of human BBOX pre-incubated for 25 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human BBOX pre-incubated for 20 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
Inhibition of human BBOX pre-incubated for 15 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 8 Tested
Inhibition of human BBOX pre-incubated for 10 mins using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 8 Tested
Inhibition of human BBOX pre-incubated for 1 min using TBS-protected fluorescein probe and Fe (II) (Fe(NH4)2(SO4)2 salt by fluoride release assay
Binding affinity to purified human BBOX by isothermal titration calorimetry analysis
Assay data:2 Active, 2 Tested
Ratio of mildronate IC50 to compound IC50 for human recombinant BBOX
Assay data:3 Tested
Inhibition of human recombinant BBOX expressed in Saccharomyces cerevisiae AH22 assessed as formation of carnitine from gamma-butyrobetaine preincubated for 15 mins measured after 30 mins by UPLC-MS/MS analysis
Assay data:21 Active, 8 Activity ≤ 1 µM, 52 Tested
Inhibition of BBOX (unknown origin)
Inhibition of human BBOX1 by fluorescence based assay
Assay data:10 Tested
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