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Cellular Firefly Luciferase Assay (AP-1) from US Patent US9187397: "Therapeutic curcumin derivatives"
Assay data:7 Active, 9 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of LPS-induced AP-1 activity in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 12 hrs by luciferase reporter gene assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of c-JUN in HUVEC assessed as reduction of c-JUN transcriptional activity by genome-wide RNA-seq and ChlP-seq analysis
SummaryRelated BioAssays by Target
Inhibition of AP-1 (unknown origin) expressed in mouse JB6 Cl41 cells at 25 uM after 24 hrs by luciferase reporter gene assay relative to control
Inhibition of AP-1 (unknown origin) expressed in mouse JB6 Cl41 cells after 24 hrs by luciferase reporter gene assay
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Effect on c-Jun at S63 phosphorylation level in human NCI-H1975 incubated for 12 hrs by human phosphokinase proteome profiler array relative to beta-catenin
Assay data:2 Tested
Effect on c-Jun phosphorylation at S63 residue in human NCI-H1975 cells incubated for 12 hrs by human phosphokinase proteome profiler array relative to control
Inhibition of LPS-induced AP1 nuclear translocation in mouse BV2 cells pre-incubated before LPS stimulation by immunostaining based confocal laser microscopy
Assay data:3 Active, 3 Tested
Activation of AP1 (unknown origin) expressed in mouse RAW264.7 cells at 25 uM after 24 hrs by SEAP reporter gene based spectrophotometric analysis
Assay data:1 Active, 1 Tested
Inhibition of LPS-induced nuclear translocation of AP-1 c-Fos component in mouse RAW264.7 cells up to 10 ug/ml preincubated for 2 hrs followed by LPS stimulation for 4 hrs by Western blot method
Inhibition of LPS-induced nuclear translocation of AP-1 c-Jun component in mouse RAW264.7 cells up to 10 ug/ml preincubated for 2 hrs followed by LPS stimulation for 4 hrs by Western blot method
Inhibition of AP-1 (unknown origin) activation expressed in LPS-stimulated mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation for 4 hrs by luciferase reporter gene assay
Inhibition of c-Jun phosphorylation in human PC3 cells after 48 hrs by Western blot analysis
Inhibition of TGFbeta1-induced AP-1 binding activity in human SNU182 cells at 20 to 40 uM measured after 48 hrs in presence of (E)-1-(9-Ethyl-9H-carbazol-3-yl)-5-(4-hydroxy-3-methoxyphenyl)pent-1-en-3-one by luciferase reporter gene assay
Inhibition of TGFbeta1-induced AP-1 binding activity in human SNU182 cells at 20 to 40 uM measured after 48 hrs in presence of zingerone by luciferase reporter gene assay
Effect on phosphorylated c-jun in EGF-stimulated mouse JB6 P+ cells at 0.25 to 1 uM preincubated for 1 hr followed by EGF stimulation
Inhibition of LPS-induced c-JUN phosphorylation in mouse RAW264.7 cells at 50 uM pretreated for 1 hr followed by LPS-stimulation measured up to 30 mins by Western blot analysis
Inhibition of AP1 (unknown origin) expressed in LPS-stimulated mouse RAW264.7 cells at 12.5 to 50 uM pretreated for 1 hr followed by LPS-stimulation measured after 18 hrs by luciferase reporter gene assay
Inhibition of c-jun phosphorylation in peptidoglycan-stimulated mouse RAW264.7 cells at 6 uM pretreated for 30 mins followed by peptidoglycan stimulation for 30 mins by Western blot method
Inhibition of AP-1 activation in human PMA/ionomycin stimulated Jurkat T cells at 10 uM by renilla luciferase reporter gene assay relative to control
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