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Antagonist activity at human LPA5 receptor assessed as inhibition of LPS-induced cAMP accumulation incubated for 20 mins
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human LPA5 receptor by FLIPR analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Antagonist activity at human LPA5 receptor expressed in CHO cells assessed as inhibition of LPA stimulated calcium release incubated for 20 mins followed by LPS stimulation and measured for 90 seconds
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Receptor Assay from US Patent US9464060: "Compounds"
Assay data:83 Active, 4 Activity ≤ 1 nM, 80 Activity ≤ 1 µM, 83 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
PRESTO-Tango GPCRome screening (LPAR5)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of LPA5 (unknown origin)
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human LPA5 expressed in rat B103 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay
Antagonist activity at LPA receptor 5 (unknown origin) assessed as inhibition of LPA induced calcium mobilization at 0.01 to 10 uM after 30 mins by fluorescence analysis
Agonist activity at LPA receptor 5 (unknown origin) assessed as calcium mobilization after 30 mins by fluorescence analysis
Agonist activity at FLAG-tagged LPA5 receptor (unknown origin) expressed in rat B103 cells assessed as increase in intracellular calcium level measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at FLAG-tagged LPA5 receptor (unknown origin) expressed in rat B103 cells assessed as inhibition of LPA-induced intracellular calcium level up to 100 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay
Assay data:5 Tested
Agonist activity at FLAG-tagged LPA5 receptor (unknown origin) expressed in rat B103 cells assessed as increase in intracellular calcium level up to 10 uM measured every 3.42 secs for 70 secs by Fura-2-AM dye based fluorescence assay
Assay data:3 Tested
Human LPA5 receptor (Lysophospholipid (LPA) receptors)
Assay data:5 Active, 5 Tested
Rat LPA5 receptor (Lysophospholipid (LPA) receptors)
Assay data:2 Active, 2 Tested
Antagonist activity at human LPA5 receptor expressed in rat B103 cells assessed as inhibition of LPA-induced calcium mobilization preincubated for 30 mins followed by LPA induction by FLIPR Calcium 4 dye-based fluorometric analysis
Agonist activity at FLAG-tagged human LPA5 expressed in rat B103 cells by Fura-2AM dye based Ca2+ mobilization assay relative to LPA 18:1
Assay data:15 Tested
Agonist activity at FLAG-tagged human LPA5 expressed in rat B103 cells by Fura-2AM dye based Ca2+ mobilization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 16 Tested
Agonist activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425
Assay data:11 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Intrinsic activity at human LPA5 receptor transfected in HEK293 cells after 1 hr by TGFalpha shedding assay in presence of Ki16425 relative to LPA
Assay data:11 Tested
Antagonist activity at human recombinant LPA5 receptor expressed in rat RH7777 cells assessed as inhibition of hexadecyl-LPA-induced effect
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