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Drug metabolism in human hepatocytes assessed as formation of FMO-mediated N,N-Dimethyl-3-[[5-(3-methyl-2-oxo-1-tetrahydropyran-4-yl-imidazo[4,5c]quinolin-8-yl)-2-pyridyl]oxy]propan-1-amine oxide
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in absence of human liver cytosolic fractions at 50 uM after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in absence of dog liver cytosolic fractions at 50 uM after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in absence of rat liver cytosolic fractions at 50 uM after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated compound formation from 50 uM E7016 in presence of dog liver cytosolic fractions after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated compound formation from 50 uM E7016 in presence of human liver cytosolic fractions after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated compound formation from 50 uM E7016 in presence of rat liver cytosolic fractions after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in presence of human liver cytosolic fractions at 50 uM after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in presence of dog liver cytosolic fractions at 50 uM after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in presence of rat liver cytosolic fractions at 50 uM after 60 mins by LC-MS/MS method
Drug level assessed as human recombinant FMO5-mediated compound formation from 10 uM ER-879819 in presence NADH after 60 mins by LC-MS/MS method
Drug level assessed as human recombinant FMO5-mediated compound formation from 10 uM ER-879819 in presence NADPH after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in presence NADH at 10 uM after 60 mins by LC-MS/MS method
Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation at 10 uM after 60 mins by LC-MS/MS method in presence of NADPH
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