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Inhibition of TGF-beta (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryRelated BioAssays by Target
Inhibition of TGF-beta receptor (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of TGF-beta1/Smad3 signalling in TGF-beta1 treated mouse NIH3T3 cells transfected with (CAGA)12-Lux reporter gene incubated for 18 hrs by luciferase based analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TGF-beta1/Smad3 signalling in in TGF-beta1 treated mouse NIH3T3 cells transfected with (CAGA)12-Lux reporter gene assessed as suppression ratio at 10 uM incubated for 18 hrs by luciferase based analysis
Inhibition of TGF-beta1/Smad3 signalling in TGF-beta1 treated mouse NIH3T3 cells transfected with (CAGA)12-Lux reporter gene assessed as suppressive ratio at 10 uM incubated for 18 hrs by luciferase based analysis relative to control
Assay data:36 Tested
Inhibition of TGF beta 1 (unknown origin) expressed in HEK293 cells transfected with Smad2/3 responsive reporter plasmid incubated for 4 hrs by dual luciferase reporter gene assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TGFbeta1 (unknown origin) expressed in HEK293 cells at 0.3 to 10 uM incubated for 4 hrs by dual luciferase reporter gene assay
Inhibition of TGF beta1/Smad3 signaling in mouse NIH/3T3 cells harboring CAGA promoter incubated for 18 hrs in presence of TGF-beta1 by luciferase reporter gene assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TGF beta1/Smad3 signaling in mouse NIH/3T3 cells harboring CAGA promoter at 10 uM incubated for 18 hrs in presence of TGF-beta1 by luciferase reporter gene assay relative to control
Assay data:2 Tested
Inhibition of TGFbeta/Smad3 pathway in rat NRK-49F cells assessed as reduction in TGF-beta1-induced Smad3 phosphorylation at 20 and 40 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
Inhibition of TGFbeta/Smad3 pathway in rat NRK-49F cells assessed as reduction in TGF-beta1-induced alpha-SMA expression in at 20 and 40 uM incubated for 24 hrs by Western blot analysis
Inhibition of TGFbeta/Smad3 pathway in rat NRK-49F cells assessed as reduction in TGF-beta1-induced COL1A1 expression in at 20 and 40 uM incubated for 24 hrs by Western blot analysis
Inhibition of TGF-beta1/smad3 signaling pathway in human HFL cells assessed as decrease in smad3 phosphorylation at 10 uM after 30 mins by Western blot analysis
Inhibition of TGF-beta1/smad3 signaling pathway in human HFL cells assessed as decrease in Col1 protein expression level at 10 uM after 24 hrs by Western blot analysis
Inhibition of TGF-beta1/smad3 signaling pathway in human HFL cell extract assessed as decrease in alpha-SMA protein expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of TGF-beta1/smad3 signaling pathway in mouse NIH/3T3 cell extract assessed as decrease in Smad3 phosphorylation at 10 uM after 30 mins by Western blot analysis
Assay data:3 Active, 3 Tested
Inhibition of TGF-beta1/smad3 signaling pathway in mouse NIH/3T3 cells assessed as decrease in ECM production at 10 uM after 24 hrs
Inhibition of TGF-beta1/smad3 signaling pathway in mouse NIH/3T3 cell extract assessed as decrease in alpha-SMA protein expression at 10 uM after 24 hrs by Western blot analysis
Inhibition of TGF-beta1/smad3 signaling pathway in mouse NIH/3T3 cells at 5 to 40 uM after 18 hrs by CAGA-luciferase reporter gene assay
Inhibition of TGF-beta1/smad3 signaling pathway in mouse NIH/3T3 cells at 40 uM after 18 hrs by CAGA-luciferase reporter gene assay
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