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ITK Enzyme Assay from US Patent US20230280220: "Benzimidazole Derivative Compounds and Uses Thereof"
Assay data:54 Active, 2 Activity ≤ 1 nM, 54 Activity ≤ 1 µM, 54 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ITK Enzyme Assay from US Patent US11661419: "Benzimidazole derivative compounds and uses thereof"
Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a ITK
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction ( p-PLCg1 assay) EUB0000646a ITK
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (Z?-LYTE assay) EUB0000638a ITK
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ITK (unknown origin) at 0.3 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human ITK assessed as residual activity at 30 uM relative to control
Inhibition of ITK (unknown origin) by lanthascreen Tb kinase activity assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ITK (unknown origin) at 0.5 uM assessed as competition rate relative to control
Inhibition of ITK (unknown origin) at 0.5 uM relative to control
Inhibition of ITK (unknown origin)
Assay data:2 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to ITK (unknown origin) assessed as dissociation constant by KINOMEscan analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 6 Tested
Assay data:2 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human N-terminal His6 tagged ITK (354 to 620 residues) expressed in Sf9 insect cells incubated for 30 mins by time-resolved fluorescence assay
Inhibition of recombinant human ITK at 10 uM for 10 mins followed by substrate addition in presence of ATP and measured after 100 mins by ADP-Glo kinase assay
Inhibition of recombinant human ITK at 10 uM for 10 mins followed by substrate addition in presence of ATP and measured after 60 mins by HTRF assay
Inhibition of Itk (unknown origin) at 1 uM
Displacement of competitive tracer from ITK (unknown origin) assessed as target occupancy at 1.5 uM preincubated for 15 mins measured for 24 hrs relative to control
Displacement of competitive tracer from ITK (unknown origin) assessed as target occupancy at 1.5 uM preincubated for 15 mins measured for 6 hrs relative to control
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