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PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level at 50 uM preincubated with compound for 24 hrs followed by compound washout and measured after 20 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/NTMT1 in human HT-29 cells assessed as reduction in NTMT1 protein level at 50 uM preincubated with compound for 24 hrs followed by compound washout and measured after 20 hrs by Western blot analysis
PROTAC activity at VHL/NTMT1 in human HT-29 cells assessed as reduction in NTMT1 protein level by measuring maximal efficacy at 50 uM measured after 24 hrs by Western blot analysis relative to control
PROTAC activity at VHL/NTMT1 in human HT-29 cells assessed as reduction in NTMT1 protein level at 50 uM measured upto 6 hrs by Western blot analysis
PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level by measuring maximal efficacy at 50 uM measured at 3 hrs by Western blot analysis relative to control
PROTAC activity at VHL/NTMT1 in human HCT-116 cells co-expressing eGFP fusion protein assessed as reduction in NTMT1 protein level by measuring reduction in eGFP fluorescence at 100 uM incubated for 24 hrs by fluorescence microscopic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level at 50 uM preincubated with MLN4924 for 2 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level at 50 uM preincubated with MG132 for 2 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
PROTAC activity at VHL/NTMT1 in human HT-29 cells assessed as reduction in NTMT1 protein level by measuring maximal efficacy at 0.1 to 50 uM incubated for 24 hrs by Western blot analysis relative to control
PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level by measuring maximal efficacy at 0.1 to 50 uM incubated for 24 hrs by Western blot analysis relative to control
PROTAC activity at VHL/NTMT1 in human HT-29 cells assessed as reduction in NTMT1 protein level at 50 uM incubated for 24 hrs by Western blot analysis
PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level at 50 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
PROTAC activity at VHL/NTMT1 in human HT-29 cells assessed as reduction in NTMT1 protein level incubated for 24 hrs by Western blot analysis
Assay data:3 Tested
PROTAC activity at VHL/NTMT1 in human HCT-116 cells assessed as reduction in NTMT1 protein level incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 3 Tested
Potency index, ratio of DC541 IC50 to test compound IC50 for inhibition of NTMT1 (unknown origin) using SPKRIAKRRS(CONH2) peptide as substrate assessed as SAH production incubated for 10 mins in the presence of SAM by HPLC analysis
Assay data:4 Tested
Inhibition of NTMT1 (unknown origin) using SPKRIAKRRS(CONH2) peptide as substrate assessed as SAH production incubated for 10 mins in the presence of SAM by HPLC analysis
Assay data:6 Active, 6 Tested
Inhibition of full length NTMT1 (1 to 222 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as SAH production at 100 uM by SAHH-coupled fluorescence assay
Inhibition of human NTMT1 in human HCT116 cells assessed as reduction in me3-SET level up to 30 uM incubated for 72 hrs by western blot analysis
Inhibition of human NTMT1 in human HCT116 cells assessed as reduction in me3-RCC1 level up to 30 uM incubated for 72 hrs by western blot analysis
Inhibition of human NTMT1 in human HCT116 cells assessed as reduction in me3-SET level incubated for 72 hrs by western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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