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Inhibition of Mycobacterium tuberculosis InhA at 50 uM using trans-2-dodecenoyl-coenzyme A as substrate in presence of NADH
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Mycobacterium tuberculosis InhA at 5 uM using trans-2-dodecenoyl-Coenzyme A as substrate in presence of NADH relative to control
Inhibition of Mycobacterium tuberculosis InhA at 50 uM using trans-2-dodecenoyl-Coenzyme A as substrate in presence of NADH relative to control
Assay data:17 Tested
Inhibition of Mycobacterium tuberculosis InhA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Mycobacterium tuberculosis InhA assessed as residence time
Assay data:2 Tested
Binding affinity to Mycobacterium tuberculosis InhA
Inhibition of Mycobacterium tuberculosis InhA at 50 microM relative to control
Inhibition of Mycobacterium tuberculosis InhA S94A
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Mycobacterium tuberculosis wild type InhA
Assay data:1 Active, 1 Tested
Inhibition of Mycobacterium tuberculosis ATCC 25618 InhA
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Mycobacterial tuberculosis ATCC 25618 FabI assessed as measuring NADH consumption rate
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of Mycobacterium tuberculosis InhA using octenoyl-CoA as substrate in presence of NADH and measured for 10 mins by colorimetric assay
Inhibition of His-tagged Mycobacterium tuberculosis H37Rv InhA expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence based assay
Inhibition of recombinant hexaHis-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by colorimetric assay
Inhibition of His-tagged Mycobacterium tuberculosis H37Rv InhA expressed in Escherichia coli BL21 using 2-trans-dodecenoyl-CoA as substrate incubated for 30 mins in presence of NADH by fluorescence based assay
InhA Enzyme Inhibition Assay from Article 10.1016/j.bmc.2007.08.013: "Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides."
Assay data:17 Active, 4 Activity ≤ 1 µM, 28 Tested
Measurement of Inhibition Constants from Article 10.1021/cb0500042: "High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis."
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enoyl-CoA Reductase Inhibition Assay from Article 10.1021/cb0500042: "High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis."
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Enoyl-CoA Reductase Inhibition Assay from Article 10.1021/jm060715y: "Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis."
Assay data:30 Active, 13 Activity ≤ 1 µM, 63 Tested
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