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Non-competitive inhibition of NPC1L1 (unknown origin) assessed as decrease in Vmax at upto 150 uM by Lineweaver-burk double inverse plot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Non-competitive inhibition of NPC1L1 (unknown origin) assessed as decrease in Km at upto 150 uM by Lineweaver-burk double inverse plot analysis
Inhibition of NPC1L1in human HepG2 cells assessed as increase in intracellular cholesterol content incubated for 60 mins by filipin dye based confocal microscopy analysis
Assay data:2 Active, 2 Tested
Inhibition of NPC1L1in human HepG2 cells assessed as reduction in intracellular cholesterol content incubated for 60 mins by filipin dye based confocal microscopy analysis
Assay data:1 Active, 2 Tested
Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Non-competitive inhibition of NPC1L1 in human Caco-2 cells assessed as decrease in uptake of cholesterol at 50 uM by HPLC-MS based Lineweaver-Burk double reciprocal plot analysis
Inhibition of NPC1L1 in human Caco-2 cells assessed as decrease in uptake of cholesterol-d6 at 50 uM by HPLC-MS analysis
Assay data:3 Active, 3 Tested
Binding affinity to NPC1L1 (unknown origin) at 6.25 to 100 uM by SPR analysis
Inhibition of NPC1L1-mediated cholesterol-methyl-beta-cyclodextrin accumulation in mouse RAW264.7 cells assessed as decrease in foam cell formation by measuring decrease in MDA level
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of NPC1L1-mediated cholesterol-methyl-beta-cyclodextrin accumulation in mouse RAW264.7 cells assessed as decrease in foam cell formation by measuring decrease in LDH level
Inhibition of NPC1L1 in human Caco2 cells assessed as decrease in cholesterol uptake at 100 uM preincubated for 24 hrs followed by stigmosterol substrate addition measured after 24 hrs by HPLC method
Assay data:7 Active, 10 Tested
Inhibition of NPC1L1-mediated cholesterol-methyl-beta-cyclodextrin accumulation in mouse RAW264.7 cells assessed as decrease in foam cell formation by measuring decrease in MDA level at 30 uM relative to control
Assay data:2 Tested
Inhibition of NPC1L1-mediated cholesterol-methyl-beta-cyclodextrin accumulation in mouse RAW264.7 cells assessed as decrease in foam cell formation by measuring decrease in LDH level at 30 uM relative to control
Inhibition of NPC1L1-mediated cholesterol-methyl-beta-cyclodextrin accumulation in mouse RAW264.7 cells incubated for 72 hrs by Oil Red O/hematoxyline staining based microscopic analysis
Inhibition of NPC1L1 in mouse RAW264.7 cells assessed as decrease in choleserol-D7 absorption at 30 uM after 72 hrs by LC-MS/MS analysis relative to control
Inhibition of NPC1L1 in human Caco2 cells assessed as decrease in cholesterol uptake at 100 uM preincubated for 24 hrs followed by stigmosterol substrate addition measured after 24 hrs by HPLC method relative to control
Assay data:4 Tested
Human NPC1 like intracellular cholesterol transporter 1 (Patched family)
Inhibition of niemann pick C1-like protein-1 in human Caco-2 cells assessed as cholesterol uptake at 100 uM after 24 hrs by HPLC analysis
Assay data:7 Active, 9 Tested
Binding affinity to human GFP-tagged NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as localization to plasma membrane at 10 uM after 24 hrs by fluorescence microscopic analysis
Assay data:57 Tested
Binding affinity to human EGFP-tagged NTD-deleted NPC1L1 L1072T/L1168I mutant expressed in HEK293 cells assessed as protein stabilization after 24 hrs by fluorescence assay
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