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Inhibition Assay from US Patent US9962362: "Use of small molecule inhibitors targeting EYA tyrosine phosphatase"
Assay data:3 Active, 12 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibitory Assay from US Patent US9725430: "Use of small molecule inhibitors targeting EYA tyrosine phosphatase"
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) interaction with His-tagged SIX2 using Ni-NTA agarose gel electrophoresis based pull down assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Km at 5 to 10 uM using para-nitrophenol phosphate substrate incubated for 30 mins
Assay data:1 Active, 1 Tested
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Vmax at 5 to 10 uM using para-nitrophenol phosphate substrate incubated for 30 mins
Competitive inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) at 3 to 10 uM using para-nitrophenol phosphate substrate incubated for 30 mins
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) using para-nitrophenol phosphate substrate incubated for 30 mins in presence of 0.01% Triton X-100
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) using phospho-peptide KKATQASQEpY substrate
Inhibition of mouse Eya3 catalytic domain (223 to 510 residues) using phospho-peptide KKATQASQEpY substrate
Inhibition of poly-histidine and GST-tagged full length human Eya3 isoform 2 (127 to 573 residues) using para-nitrophenol phosphate substrate incubated for 30 mins
Assay data:4 Active, 14 Tested
Inhibition of mouse Eya3 catalytic domain (223 to 510 residues) using para-nitrophenol phosphate substrate incubated for 30 mins
Assay data:3 Tested
Inhibition of human Eya3 isoform 2 (127 to 573 residues) interaction with His-tagged SIX2 at 50 uM by Ni-NTA agarose gel based pull down assay
Non-competitive inhibition of human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Vmax of substrate incubated for 30 mins by p-nitrophenylphosphate assay
Non-competitive inhibition of human Eya3 isoform 2 (127 to 573 residues) assessed as reduction in Km of substrate incubated for 30 mins by p-nitrophenylphosphate assay
Non-competitive inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins using increasing levels of pNPP substrate
Inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins in presence of 0.01% Triton X-100 by p-nitrophenylphosphate assay
Inhibition of mouse Eya3 catalytic domain (223 to 510 residues) in presence of 0.01% Triton X-100 by p-nitrophenylphosphate assay
Inhibition of human Eya3 isoform 2 (127 to 573 residues) using KKATOASQEpY phospho-peptide substrate
Inhibition of mouse Eya3 catalytic domain (223 to 510 residues) using KKATOASQEpY phospho-peptide substrate
Inhibition of human Eya3 isoform 2 (127 to 573 residues) incubated for 30 mins by p-nitrophenylphosphate assay
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