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Inhibition of DNA polymerase alpha (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of POLA1 in human NCI-H460 cells at 7.4 uM assessed as upregulation of p21 expression and measured by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of POLA1 in human NCI-H460 cells at 0.1 to 0.4 uM assessed as upregulation of p21 expression and measured by Western blot analysis
Assay data:3 Active, 3 Tested
Inhibition of recombinant POLA1 (unknown origin) using 5-Fluorescein-rGrGrArArArGrGrArCrGrArArArCrA-3 as substrate at 10 to 50 uM and measured by primer extension assay
Assay data:2 Active, 2 Tested
Inhibition of human DNA polymerase alpha at 100 uM incubated for 60 mins by Microbeta counter analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at human DNA polymerase alpha using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 60 mins and at 80 degreeC for 3 mins by primer extension assay
Assay data:2 Tested
Inhibition of human DNA polymerase alpha
Substrate activity at human DNA polymerase alpha incubated at 37 degC for 60 mins and at 80 degC for 7 mins by primer extension assay
Assay data:3 Tested
Substrate activity at human DNA polymerase alpha assessed as increase in primer extension incubated at 37 degC for 60 mins and at 80 degC for 3 mins in presence of fluorescent-lebelled dATP, dCTP and dGTP by PAGE analysis
Inhibition of human DNA polymerase alpha at 100 uM using calf DNA as substrate by microbeta scintillation counting method relative to control
Assay data:6 Tested
Inhibition of human DNA polymerase-alpha (unknown origin)
Inhibition of human DNA polymerase-alpha by fluorescence/radiometric assay
Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP by PAGE analysis
Assay data:1 Active, 2 Tested
Inhibition of human DNA polymerase-alpha assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 100 uM by scintillation counting method relative to control
Assay data:8 Tested
Inhibition of human DNA polymerase-alpha assessed as reduction in [3H]dTTP incorporation in to activated calf thymus DNA substrate at 600 uM after 30 mins by scintillation counting method relative to control
Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysis
Assay data:1 Active, 3 Tested
Inhibition of recombinant human DNA polymerase alpha preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma-33P]TTP by phosphorimaging assay
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