Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Binding affinity to HuR (unknown origin) assessed as interaction of ring A and protons 16 with hydrophobic residues and projection of ring B and its methoxy group with polar residues of protein at 400 uM in H2O:D2O (90:10) buffer by DEEP-STD NMR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to HuR (unknown origin) assessed as negative STD factor by measuring interaction of protons 3, 9-10 and 16 with protein at 400 uM in 100% D2O buffer by DEEP-STD NMR analysis
Binding affinity to HuR (unknown origin) assessed as interaction of ring A and protons 5 and 3 with apolar residues and projection of protons 16 and 9-10 with polar residues of protein at 400 uM in H2O:D2O (90:10) buffer by DEEP-STD NMR analysis
Binding affinity to HuR (unknown origin) assessed as positive STD factor by measuring interaction of protons of ring B and its methoxy group with protein at 400 uM in 100% D2O buffer by DEEP-STD NMR analysis
Binding affinity to HuR (unknown origin) assessed as absolute STD percentage for ring C moiety by 1H-STD-NMR spectroscopic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to HuR (unknown origin) assessed as absolute STD percentage for pyridone moiety by 1H-STD-NMR spectroscopic analysis
Binding affinity to HuR (unknown origin) assessed as absolute STD percentage for protons of the amino chain (H14, H15, and H16) by 1H-STD-NMR spectroscopic analysis
Binding affinity to HuR (unknown origin) assessed as absolute STD percentage for ring A moiety by 1H-STD-NMR spectroscopic analysis
Assay data:2 Tested
Binding affinity to HuR (unknown origin) assessed as absolute STD percentage for ring B moiety by 1H-STD-NMR spectroscopic analysis
Binding affinity to HuR (unknown origin) assessed as absolute STD percentage for isopropyl moiety by 1H-STD-NMR spectroscopic analysis
Change in HuR localization from nucleus to cytoplasm in human MCF7 cells at 1 uM after 3 hrs by DAPI staining-based immunofluorescence method
Change in HuR localization from nucleus to cytoplasm in human MCF7 cells at 10 uM after 3 hrs by DAPI staining-based immunofluorescence method
Assay data:5 Tested
Stabilization of closed conformation of human full length recombinant HuR RRM1-RRM2 domain at 0.6 equiv by 2D 1H 15N HSQC spectra analysis
Inhibition of HuR-VEGF mRNA interaction in human MCF7 cells at 5 uM after 6 hrs by qRT-PCR method
Inhibition of HuR-CTNNB1 mRNA interaction in human MCF7 cells at 5 uM after 6 hrs by qRT-PCR method
Inhibition of HuR-ERBB2 mRNA interaction in human MCF7 cells at 5 uM after 6 hrs by qRT-PCR method
Inhibition of HuR-VEGF mRNA interaction in human MCF7 cells at 5 uM after 6 hrs by RNA immunoprecipitation assay
Inhibition of HuR-CTNNB1 mRNA interaction in human MCF7 cells at 5 uM after 6 hrs by RNA immunoprecipitation assay
Inhibition of HuR-ERBB2 mRNA interaction in human MCF7 cells at 5 uM after 6 hrs by RNA immunoprecipitation assay
Binding affinity to human recombinant HuR RRM3 domain expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction with 5'-DY681-labeled AU-rich RNA probe at 0.3 to 10 uM after 30 mins by REMSA
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on